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尼日利亚东南部私立和公共卫生机构的抗疟药物处方实践:一项描述性研究。

Antimalarial drug prescribing practice in private and public health facilities in South-east Nigeria: a descriptive study.

作者信息

Meremikwu Martin, Okomo Uduak, Nwachukwu Chukwuemeka, Oyo-Ita Angela, Eke-Njoku John, Okebe Joseph, Oyo-Ita Esu, Garner Paul

机构信息

Institute of Tropical Diseases Research and Prevention, University of Calabar Teaching Hospital, Calabar, Nigeria.

出版信息

Malar J. 2007 May 4;6:55. doi: 10.1186/1475-2875-6-55.

Abstract

BACKGROUND

Nigeria's national standard has recently moved to artemisinin combination treatments for malaria. As clinicians in the private sector are responsible for attending a large proportion of the population ill with malaria, this study compared prescribing in the private and public sector in one State in Nigeria prior to promoting ACTs.

OBJECTIVE

To assess prescribing for uncomplicated malaria in government and private health facilities in Cross River State.

METHOD

Audit of 665 patient records at six private and seven government health facilities in 2003.

RESULTS

Clinicians in the private sector were less likely to record history or physical examination than those in public facilities, but otherwise practice and prescribing were similar. Overall, 45% of patients had a diagnostic blood slides; 77% were prescribed monotherapy, either chloroquine (30.2%), sulphadoxine-pyrimethamine (22.7%) or artemisinin derivatives alone (15.8%). Some 20.8% were prescribed combination therapy; the commonest was chloroquine with sulphadoxine-pyrimethamine. A few patients (3.5%) were prescribed sulphadoxine-pyrimethamine-mefloquine in the private sector, and only 3.0% patients were prescribed artemisinin combination treatments.

CONCLUSION

Malaria treatments were varied, but there were not large differences between the public and private sector. Very few are following current WHO guidelines. Monotherapy with artemisinin derivatives is relatively common.

摘要

背景

尼日利亚的国家标准最近已转向采用青蒿素联合疗法治疗疟疾。由于私营部门的临床医生负责诊治很大一部分疟疾患者,本研究在推广青蒿素联合疗法之前,对尼日利亚一个州的私营和公共部门的处方情况进行了比较。

目的

评估克罗斯河州政府和私立医疗机构对非复杂性疟疾的处方情况。

方法

2003年对6家私立和7家政府医疗机构的665份患者记录进行审计。

结果

与公共机构的临床医生相比,私营部门的临床医生记录病史或进行体格检查的可能性较小,但在其他方面,诊疗行为和处方情况相似。总体而言,45%的患者进行了诊断性血涂片检查;77%的患者接受了单一疗法,其中氯喹(30.2%)、磺胺多辛-乙胺嘧啶(22.7%)或仅青蒿素衍生物(15.8%)。约20.8%的患者接受了联合疗法;最常见的是氯喹与磺胺多辛-乙胺嘧啶联合使用。少数患者(3.5%)在私营部门接受了磺胺多辛-乙胺嘧啶-甲氟喹治疗,只有3.0%的患者接受了青蒿素联合疗法。

结论

疟疾治疗方法多种多样,但公共和私营部门之间没有很大差异。很少有人遵循世界卫生组织目前的指南。青蒿素衍生物单一疗法相对普遍。

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