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本文引用的文献

1
Malaria parasitaemia among febrile under-five children at Nnamdi Azikiwe University Teaching Hospital, Nnewi, South-East, Nigeria.尼日利亚东南部Nnewi的纳姆迪·阿齐克韦大学教学医院五岁以下发热儿童的疟疾寄生虫血症
Niger J Med. 2016 Apr-Jun;25(2):113-18.
2
Knowledge and Adherence to the National Guidelines for Malaria Case Management in Pregnancy among Healthcare Providers and Drug Outlet Dispensers in Rural, Western Kenya.肯尼亚西部农村地区医疗服务提供者和药品零售店药剂师对疟疾孕期病例管理国家指南的知晓与依从情况
PLoS One. 2016 Jan 20;11(1):e0145616. doi: 10.1371/journal.pone.0145616. eCollection 2016.
3
Adherence to treatment with artemether-lumefantrine for uncomplicated malaria in rural Malawi.在马拉维农村,采用青蒿琥酯-咯萘啶治疗无并发症疟疾的患者治疗依从性。
Clin Infect Dis. 2011 Oct;53(8):772-9. doi: 10.1093/cid/cir498.
4
Impact of malaria at the end of pregnancy on infant mortality and morbidity.孕期末期疟疾对婴儿死亡率和发病率的影响。
J Infect Dis. 2011 Mar 1;203(5):691-9. doi: 10.1093/infdis/jiq049. Epub 2011 Jan 3.
5
Successful introduction of artesunate combination therapy is not enough to fight malaria: results from an adherence study in Sierra Leone.青蒿琥酯联合疗法的成功引入不足以抗击疟疾:来自塞拉利昂的一项依从性研究结果。
Trans R Soc Trop Med Hyg. 2010 May;104(5):328-35. doi: 10.1016/j.trstmh.2009.12.008. Epub 2010 Feb 2.
6
Placental malaria and low birth weight in pregnant women living in a rural area of Burkina Faso following the use of three preventive treatment regimens.布基纳法索农村地区孕妇在采用三种预防性治疗方案后出现的胎盘疟疾与低出生体重情况
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Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi.在马拉维测量蒿甲醚-本芴醇、氯胍-氨苯砜或磺胺多辛-乙胺嘧啶治疗单纯性疟疾的依从性、药物浓度及疗效。
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Pattern of drug utilization for treatment of uncomplicated malaria in urban Ghana following national treatment policy change to artemisinin-combination therapy.加纳城市地区在国家治疗政策变更为采用青蒿素联合疗法后,用于治疗非复杂性疟疾的药物使用模式。
Malar J. 2009 Jan 5;8:2. doi: 10.1186/1475-2875-8-2.
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Adherence and effectiveness of drug combination in curative treatment among children suffering uncomplicated malaria in rural Senegal.塞内加尔农村地区单纯性疟疾患儿药物联合治疗的依从性及疗效
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10
Why don't health workers prescribe ACT? A qualitative study of factors affecting the prescription of artemether-lumefantrine.卫生工作者为何不开具蒿甲醚-本芴醇(ACT)处方?一项关于影响蒿甲醚-本芴醇处方因素的定性研究。
Malar J. 2008 Feb 5;7:29. doi: 10.1186/1475-2875-7-29.

尼日利亚三角州医生对抗疟药政策的依从性:对疟疾控制的影响

Adherence to antimalarial drug policy among doctors in Delta State, Nigeria: implications for malaria control.

作者信息

Obiebi Irikefe P

机构信息

Department of Community Medicine, Delta State University Teaching Hospital, Oghara.

出版信息

Ghana Med J. 2019 Jun;53(2):109-116. doi: 10.4314/gmj.v53i2.5.

DOI:10.4314/gmj.v53i2.5
PMID:31481806
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6697767/
Abstract

BACKGROUND

Malaria is a public health problem compounded with a widespread emergence of drug-resistant Plasmodium falciparum which necessitated the formulation of a new antimalarial drug policy (AMP).

OBJECTIVE

This study was designed to assess adherence to the policy among physicians in health facilities in Delta state, Nigeria.

DESIGN

Cross-sectional, analytic study. Data were collected with a semi-structured questionnaire.

SETTING

Two secondary and one tertiary health facilities in Delta State, Nigeria.

PARTICIPANTS

Physicians selected with a simple random technique from the facilities.

MAIN OUTCOME MEASURES

Prescribing pattern of antimalarial drugs and adherence to WHO treatment guideline among doctors.

RESULTS

Majority (90.8%) of respondents believed the antimalarial policy (AMP) should be strictly adhered to, although three-fifth (61.0%) of them rated its performance as poor. The level of adherence to the national antimalarial drug policy was high (78.5%) as most doctors prescribed Arthemeter-Lumefantrine, AL for uncomplicated malaria however barely two-fifth (35.4%) adhered to prescribing injectable Artesunate for complicated malaria. AL, (71.9%) was the most prescribed antimalarial drug for uncomplicated malaria The most prescribed antimalarial drugs for complicated malaria was artesunate (40.0%) followed by quinine (27.6%) and artemether (26.7%); although, chloroquine was also prescribed.

CONCLUSION

The level of adherence to AMP among doctors was sub-optimal. Continuous education of doctors on the new AMP is needed to achieve malarial control.

FUNDING

No funding was received for this study.

摘要

背景

疟疾是一个公共卫生问题,恶性疟原虫耐药性的广泛出现使这一问题更加复杂,因此需要制定新的抗疟药物政策(AMP)。

目的

本研究旨在评估尼日利亚三角州医疗机构的医生对该政策的遵守情况。

设计

横断面分析研究。通过半结构化问卷收集数据。

地点

尼日利亚三角州的两家二级医疗机构和一家三级医疗机构。

参与者

从这些机构中采用简单随机技术选取医生。

主要观察指标

抗疟药物的处方模式以及医生对世界卫生组织治疗指南的遵守情况。

结果

大多数(90.8%)受访者认为应严格遵守抗疟政策(AMP),尽管其中五分之三(61.0%)的人认为该政策执行情况不佳。对国家抗疟药物政策的遵守程度较高(78.5%),因为大多数医生为非复杂性疟疾开了蒿甲醚-本芴醇(AL),然而,只有五分之二(35.4%)的医生坚持为复杂性疟疾开注射用青蒿琥酯。AL(71.9%)是治疗非复杂性疟疾最常开具的抗疟药物。治疗复杂性疟疾最常开具的抗疟药物是青蒿琥酯(40.0%),其次是奎宁(27.6%)和蒿甲醚(26.7%);不过,也有医生开具氯喹。

结论

医生对AMP的遵守程度未达最佳。需要持续对医生进行关于新AMP的教育,以实现疟疾控制。

资金

本研究未获得资金支持。