Bach L A, Cox A J, Jerums G
Endocrine Unit, Austin Hospital, Heidelberg, Victoria, Australia.
Diabetes Res Clin Pract. 1991 Oct;14(1):15-20. doi: 10.1016/0168-8227(91)90048-i.
The effects of castration on diabetes-related renal growth and IGF-I regulation were studied. In the rat, prepubertal castration is associated with a normal or increased surge in plasma insulin-like growth factor I (IGF-I) at the time of 'puberty'. In order to determine the role of sex steroids in the development of diabetes-related kidney growth and IGF-I regulation, Sprague-Dawley rats were castrated at the age of 4 weeks and streptozotocin diabetes was induced at the age of 13 weeks. The development of renal enlargement and kidney IGF-I levels was studied over the following 7 days. Kidney weight in diabetic animals was significantly greater than in controls, and by day 7, had increased by 27% (1.20 +/- 0.03 vs 0.94 +/- 0.03 g, P less than 0.001). Kidney IGF-I content was significantly elevated in diabetic rats, peaking on day 1 (diabetic, 1159 +/- 302 ng/g vs control, 237 +/- 53 ng/g, P less than 0.001) and remaining higher than control levels throughout the 7 days of the experiment. The pattern of diabetes-related kidney growth and IGF-I regulation in castrated rats resembles that of age matched intact postpubertal controls, suggesting that sex steroids do not have a direct role in these phenomena.
研究了去势对糖尿病相关肾脏生长和胰岛素样生长因子-I（IGF-I）调节的影响。在大鼠中，青春期前去势与“青春期”时血浆IGF-I正常或升高的激增有关。为了确定性类固醇在糖尿病相关肾脏生长和IGF-I调节发展中的作用，将4周龄的Sprague-Dawley大鼠去势，并在13周龄时诱导链脲佐菌素糖尿病。在接下来的7天内研究肾脏肿大和肾脏IGF-I水平的发展。糖尿病动物的肾脏重量显著大于对照组，到第7天，增加了27%（1.20±0.03对0.94±0.03 g，P<0.001）。糖尿病大鼠的肾脏IGF-I含量显著升高，在第1天达到峰值（糖尿病组，1159±302 ng/g对对照组，237±53 ng/g，P<0.001），并在实验的7天内一直高于对照组水平。去势大鼠中糖尿病相关肾脏生长和IGF-I调节的模式类似于年龄匹配的完整青春期后对照组，表明性类固醇在这些现象中没有直接作用。
