Van Eijkeren M A, Peters P J, Geuze H J
Department of Obstetrics and Gynaecology, University Hospital, Utrecht, The Netherlands.
Eur J Immunol. 1991 Dec;21(12):3049-52. doi: 10.1002/eji.1830211223.
The localization of major histocompatibility complex (MHC) class I molecules in human endometrial and endocervical epithelial cells was studied with an immunogold technique on ultrathin cryosections. At the cell surface, MHC class I molecules are delivered solely to the basolateral plasma membrane in human epithelia. Therefore, only the basolateral domain of epithelial cells is capable of presenting antigen to MHC class I-restricted cytotoxic T cells.
采用免疫金技术在超薄冷冻切片上研究了主要组织相容性复合体（MHC）I类分子在人子宫内膜和宫颈上皮细胞中的定位。在细胞表面，MHC I类分子仅被递送至人上皮细胞的基底外侧质膜。因此，只有上皮细胞的基底外侧结构域能够将抗原呈递给MHC I类限制性细胞毒性T细胞。
