Umezu M, Kawada K, Miwa A, Ishii S, Masaki J
Laboratory of Animal Reproduction, Faculty of Agriculture, Tohoku University, Miyagi, Japan.
Jikken Dobutsu. 1991 Oct;40(4):511-5. doi: 10.1538/expanim1978.40.4_511.
Koto et al found a new hereditary dwarf mutation from breeding colony of Wistar-Imamichi rat and named 'rdw'. To characterize endocrinological functions in rdw rats, pituitary and plasma levels of pituitary hormones including growth hormone (GH), follicle stimulating hormone (FSH) and luteinizing hormone (LH) were compared between rdw and normal rats. The hormone levels were estimated with radioimmunoassay (RIA). It was found that pituitary and plasma levels of GH of rdw were drastically decreased and those of FSH and LH were inclined to decrease but not remarkable as compared with normal. Rats of rdw were, therefore, considered to be useful as a model animal for endocrinological defects.
河藤等人从Wistar-Imamichi大鼠繁殖群体中发现了一种新的遗传性侏儒突变，并将其命名为“rdw”。为了表征rdw大鼠的内分泌功能，比较了rdw大鼠和正常大鼠垂体中垂体激素（包括生长激素（GH）、促卵泡激素（FSH）和促黄体生成素（LH））的水平以及血浆中这些激素的水平。采用放射免疫分析法（RIA）测定激素水平。结果发现，rdw大鼠垂体和血浆中的GH水平急剧下降，FSH和LH水平倾向于下降，但与正常大鼠相比并不显著。因此，rdw大鼠被认为是一种用于内分泌缺陷研究的有用模型动物。
