Lin Hsin Hsin, Wang Min Xia, Spies Judith M, Pollard John D
Department of Medicine, The University of Sydney, Sydney, Australia.
J Neuroimmunol. 2007 May;186(1-2):133-40. doi: 10.1016/j.jneuroim.2007.03.016. Epub 2007 May 4.
IV immunoglobulin (IVIg) and its Fc fragment proved effective in preventing further progression of experimental autoimmune neuritis (EAN) in the rat induced by whole bovine peripheral nerve myelin and shortening disease duration. This effectiveness was associated with significant differences in electrophysiological parameters including less prolongation of somatosensory evoked potential (S wave) latencies, better maintained S wave amplitudes, less reduction of distal motor nerve conduction velocity, and better maintained amplitudes of compound muscle action potentials of dorsal foot muscles after stimulation at ankle and hip. Moreover, treatment with IVIg and Fc fragments resulted in less extensive inflammation and demyelination in nerve roots evidenced by significantly lower histological grades. The current study provides direct evidence for the first time that Fc fraction of IVIg is the effective component in the treatment of rat EAN.
静脉注射免疫球蛋白（IVIg）及其Fc片段在预防全牛周围神经髓鞘诱导的大鼠实验性自身免疫性神经炎（EAN）进一步进展及缩短病程方面被证明是有效的。这种有效性与电生理参数的显著差异有关，包括体感诱发电位（S波）潜伏期延长较少、S波振幅维持较好、远端运动神经传导速度降低较少，以及在踝关节和髋关节刺激后背足肌复合肌肉动作电位的振幅维持较好。此外，IVIg和Fc片段治疗导致神经根炎症和脱髓鞘范围较小，组织学分级显著降低证明了这一点。本研究首次提供了直接证据，表明IVIg的Fc部分是治疗大鼠EAN的有效成分。
