Jassem Jacek
Department of Oncology and Radiotherapy, Medical University of Gdansk, Gdansk, Poland.
Radiother Oncol. 2007 May;83(2):203-13. doi: 10.1016/j.radonc.2007.04.004. Epub 2007 May 4.
Radiotherapy is one of the main treatment modalities in lung cancer, contributing to both its cure and palliation. Thoracic irradiation has traditionally been considered the mainstay of treatment in inoperable stage III non-small cell lung cancer. However, despite technical developments and the addition of chemotherapy, the curative potential of radiotherapy in this subset of patients is disappointingly poor. The role of radiotherapy as an adjunct to pulmonary resection (preoperative and postoperative) is questionable, but well-designed and executed phase III studies are lacking. An important application of radiotherapy is palliation of tumor-related symptoms in the chest and in metastatic sites, such as bones and brain. In small cell lung cancer, routine applications of radiotherapy include chest radiotherapy in limited disease and prophylactic cranial irradiation in complete responders to chemotherapy, each increasing survival by about 5%.
放射治疗是肺癌的主要治疗方式之一，对肺癌的治愈和缓解均有作用。传统上，胸部照射一直被视为不可切除的Ⅲ期非小细胞肺癌的主要治疗手段。然而，尽管技术有所发展且增加了化疗，但放射治疗对这部分患者的治愈潜力仍令人失望地低下。放射治疗作为肺切除（术前和术后）辅助治疗的作用存在疑问，但缺乏设计良好且执行到位的Ⅲ期研究。放射治疗的一个重要应用是缓解胸部及骨、脑等转移部位的肿瘤相关症状。在小细胞肺癌中，放射治疗的常规应用包括对局限期疾病进行胸部放疗以及对化疗完全缓解者进行预防性脑照射，每种方法均可使生存率提高约5%。
