Serke M, Kollmeier J
Lungenklinik Heckeshorn, Helios Klinikum Emil-von-Behring, Berlin, Germany.
Dtsch Med Wochenschr. 2007 Jun 1;132(22):1221-4. doi: 10.1055/s-2007-979402.
Lung cancer is divided into two types: non-small cell and small cell lung cancer. Small-cell lung cancer is a very aggressive rapid growing tumour type treated primarily with chemotherapy and, in the minority of patients with limited disease, with radiotherapy. Non-small cell lung cancer is treated in a multidisciplinary way with surgery, radiotherapy and chemotherapy depending on stage. Surgery is the mainstay of treatment for early stage non-small cell lung cancer patients. Adjuvant therapy has become state of the art in stage II and IIIA patients and must be considered in stage IB. Stage III patients should be treated in a multimodal way with radiotherapy and chemotherapy, and, if possible, with surgery. Treatment for every stage III patient should be discussed in a multidisciplinary team. Stage IV patients in good performance status will benefit from a combination chemotherapy, preferably platinum-based. Second line therapy has become standard and targeted therapies are under evaluation and are common in second line chemotherapy.
非小细胞肺癌和小细胞肺癌。小细胞肺癌是一种极具侵袭性、生长迅速的肿瘤类型，主要通过化疗进行治疗，少数疾病局限的患者则采用放疗。非小细胞肺癌根据分期采用手术、放疗和化疗的多学科治疗方法。手术是早期非小细胞肺癌患者的主要治疗手段。辅助治疗已成为II期和IIIA期患者的标准治疗方法，IB期患者也必须考虑采用。III期患者应采用放疗和化疗的多模式治疗，如有可能，还应进行手术。每个III期患者的治疗都应在多学科团队中进行讨论。身体状况良好的IV期患者将从联合化疗中获益，最好是铂类化疗。二线治疗已成为标准治疗方法，靶向治疗正在评估中，并且在二线化疗中很常见。
