Cui Qinghua, Yu Zhenbao, Purisima Enrico O, Wang Edwin
Biotechnology Research Institute, National Research Council Canada, Montreal, Quebec, H4P 2R2, Canada.
Trends Genet. 2007 Aug;23(8):372-5. doi: 10.1016/j.tig.2007.04.003. Epub 2007 May 4.
MicroRNAs (miRNAs) modulate expression of their target genes in various tissues and at different developmental stages, but it is unclear whether they drive cross-species variation in gene expression. By comparing data from mammal and fly species we found that the cross-species expression variation of miRNA targets is significantly lower than that of other genes. This implies that miRNAs can affect gene expression by reducing stochastic noise, buffering cross-species variation and constraining evolutionary gene expression variation.
微小RNA（miRNAs）在各种组织和不同发育阶段调节其靶基因的表达，但它们是否驱动基因表达的跨物种变异尚不清楚。通过比较哺乳动物和果蝇物种的数据，我们发现miRNA靶标的跨物种表达变异显著低于其他基因。这意味着miRNAs可以通过减少随机噪声、缓冲跨物种变异和限制进化基因表达变异来影响基因表达。
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