反应性关节炎与颞下颌关节内紊乱
Reactive arthritis and internal derangement of the temporomandibular joint.
作者信息
Henry Charles H, Whittum-Hudson Judith A, Tull Gregory T, Wolford Larry M
机构信息
Keene, NH, USA.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Jul;104(1):e22-6. doi: 10.1016/j.tripleo.2007.01.003. Epub 2007 May 7.
OBJECTIVE
The objective of this study was to determine if temporomandibular joint (TMJ) samples positive for Chlamydia trachomatis have a greater presence of tumor necrosis factor-alpha (TNFalpha) or interleukin-6 (IL-6) when compared with Chlamydia-negative samples.
STUDY DESIGN
Posterior bilaminar tissue samples removed during TMJ surgery from 70 patients were evaluated. Cryosections were stained using monoclonal antibody that identifies C. trachomatis. The presence of IL-6 and TNFalpha were evaluated by immunostaining in 15 samples positive and in 25 samples negative for the presence of C. trachomatis.
RESULTS
Of the 70 TMJ samples, 32 (46%) were positive for C. trachomatis. In 15 samples positive for C. trachomatis, 10 (67%) were positive for TNFalpha and 7 (47%) for IL-6. In 25 samples negative for C. trachomatis, only 4 (16%) were positive for TNFalpha and only 2 (8%) for IL-6. Differences in C. trachomatis-positive samples versus negative were significant for both TNFalpha (P < .002) and IL-6 (P < .008).
CONCLUSION
The presence of C. trachomatis in the TMJ is associated with a significantly increased presence of TNFalpha and IL-6.
目的
本研究的目的是确定与沙眼衣原体阴性样本相比，沙眼衣原体阳性的颞下颌关节（TMJ）样本中肿瘤坏死因子-α（TNFα）或白细胞介素-6（IL-6）的含量是否更高。
研究设计
对70例患者TMJ手术中切除的双侧后层组织样本进行评估。冰冻切片用识别沙眼衣原体的单克隆抗体染色。通过免疫染色评估15例沙眼衣原体阳性样本和25例沙眼衣原体阴性样本中IL-6和TNFα的存在情况。
结果
70例TMJ样本中，32例（46%）沙眼衣原体呈阳性。在15例沙眼衣原体阳性样本中，10例（67%）TNFα呈阳性，7例（47%）IL-6呈阳性。在25例沙眼衣原体阴性样本中，只有4例（16%）TNFα呈阳性，只有2例（8%）IL-6呈阳性。沙眼衣原体阳性样本与阴性样本在TNFα（P < .002）和IL-6（P < .008）方面的差异均具有统计学意义。
结论
TMJ中沙眼衣原体的存在与TNFα和IL-6的含量显著增加有关。
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