Landi Francesco, Russo Andrea, Capoluongo Ettore, Cesari Matteo, Liperoti Rosa, Danese Paola, Bernabei Roberto, Onder Graziano
Department of Gerontology and Geriatrics, Catholic University of Sacred Heart, Roma, Italy.
Int J Hematol. 2007 May;85(4):294-9. doi: 10.1532/IJH97.E0629.
A decreased hemoglobin concentration is a common clinical condition in elderly subjects, and in at least 20% of the cases it is not possible to directly attribute the anemia to specific factors. The aim of the present study was to evaluate the relationship of different levels of insulin-like growth factor-binding protein 3 (IGFBP-3) with the blood concentration of hemoglobin in persons aged 80 years and older. Data are from a baseline evaluation of the Aging and Longevity in the Sirente Geographic Area (ilSIRENTE) study (n=253). Analysis of covariance was used to examine the effect of different IGFBP-3 levels on hemoglobin concentration. After adjustment for potential confounding variables, which included age, sex, number of diseases, renal failure, cancer, gastric ulcer, albumin, and iron concentrations, individuals in the group with higher IGFBP-3 concentrations showed a significantly higher mean hemoglobin concentration than participants in the group with lower IGFBP-3 concentrations (13.4 +/- 1.4 g/dL versus 12.9 +/- 1.9 g/dL, respectively; P=.03). In conclusion, the present study has shown that a higher IGFBP-3 level is associated with a higher hemoglobin concentration among older people living in the community. This finding suggests that the growth hormone/IGF axis may play an important role in hematopoiesis, and it may be implicated in the age-related decline in hemoglobin concentration.
血红蛋白浓度降低是老年人群常见的临床情况，至少20%的病例中无法直接将贫血归因于特定因素。本研究的目的是评估80岁及以上人群中不同水平的胰岛素样生长因子结合蛋白3（IGFBP - 3）与血红蛋白血浓度之间的关系。数据来自锡伦特地理区域衰老与长寿（ilSIRENTE）研究的基线评估（n = 253）。采用协方差分析来检验不同IGFBP - 3水平对血红蛋白浓度的影响。在对包括年龄、性别、疾病数量、肾衰竭、癌症、胃溃疡、白蛋白和铁浓度等潜在混杂变量进行调整后，IGFBP - 3浓度较高组的个体平均血红蛋白浓度显著高于IGFBP - 3浓度较低组的参与者（分别为13.4±1.4 g/dL和12.9±1.9 g/dL；P = 0.03）。总之，本研究表明，在社区居住的老年人中，较高的IGFBP - 3水平与较高的血红蛋白浓度相关。这一发现表明，生长激素/IGF轴可能在造血过程中起重要作用，并且可能与血红蛋白浓度的年龄相关性下降有关。
