Leidhold Claudia, Voos Wolfgang
Institut für Biochemie und Molekularbiologie, Universität Freiburg, Hermann-Herder-Str. 7, D-79104 Freiburg, Germany.
Ann N Y Acad Sci. 2007 Oct;1113:72-86. doi: 10.1196/annals.1391.011. Epub 2007 May 4.
Organelles like mitochondria, chloroplasts, or the endoplasmic reticulum are essential subcompartments of eukaryotic cells that fulfill important metabolic tasks. Organellar protein homeostasis is maintained by a combination of specific protein biogenesis processes and protein quality control (PQC) mechanisms that together guarantee the functional state of the organelle. According to their endosymbiontic origin, mitochondria and chloroplasts contain internal PQC systems that consist of a cooperative network of molecular chaperones and proteases. In contrast, the endoplasmic reticulum employs the main cytosolic degradation machinery, the proteasome, for the removal of damaged or misfolded proteins. Here we present and discuss recent experimental insights into the molecular mechanisms underlying organellar PQC processes.
线粒体、叶绿体或内质网等细胞器是真核细胞中至关重要的亚区室，执行着重要的代谢任务。细胞器蛋白质稳态通过特定的蛋白质生物合成过程和蛋白质质量控制（PQC）机制共同维持，这些机制共同确保细胞器的功能状态。根据其内共生起源，线粒体和叶绿体含有内部PQC系统，该系统由分子伴侣和蛋白酶的协同网络组成。相比之下，内质网利用主要的胞质降解机制——蛋白酶体来清除受损或错误折叠的蛋白质。在此，我们展示并讨论了关于细胞器PQC过程潜在分子机制的最新实验见解。
