Salmon S, Alcindor L G, Beucler I, Ayraul-Jarrier M, Infante R, Chevet D, Polonovski J
Clin Chim Acta. 1976 Feb 2;66(3):311-8. doi: 10.1016/0009-8981(76)90230-8.
The lipid composition and apopeptide patterns of plasma LDL and VLDL have been studied in a patient with LCAT deficiency, using two-dimensional immunoelectrophoresis. After absorption of a fat meal an elevation of VLDL apopeptides C was observed. Apo-LDL also showed an abnormal relative increase of apo-C. After heparin-induced lipolysis, a shift of apo-C from chylomicra and VLDL to LDL was noticed by the striking increase of apo-C in this last lipoprotein class. In view of the present and previously published results the possible mechanisms involved in lipoprotein catabolism in LCAT deficiency are discussed.
利用二维免疫电泳技术，对一名卵磷脂胆固醇酰基转移酶（LCAT）缺乏症患者的血浆低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）的脂质组成及载脂蛋白模式进行了研究。摄入脂肪餐后，观察到VLDL载脂蛋白C升高。载脂蛋白-LDL中的载脂蛋白C也出现异常相对增加。肝素诱导脂解后，发现载脂蛋白C从乳糜微粒和VLDL转移至LDL，表现为最后一类脂蛋白中载脂蛋白C显著增加。鉴于目前及此前发表的结果，讨论了LCAT缺乏症中脂蛋白分解代谢可能涉及的机制。
