Kimura Go, Puchkov Maxim, Betz Gabriele, Leuenberger Hans
Institute of Pharmaceutical Technology, Pharmacenter, University of Basel, Basel, Switzerland.
Pharm Dev Technol. 2007;12(1):11-9. doi: 10.1080/10837450601166494.
The objective of the present work is to investigate the presence or absence of a critical concentration of maize starch according to the percolation theory for a truly ternary system with respect to a minimum disintegration time. The results of this study show that the application of percolation theory is not limited to the study of binary systems. In this work it is shown how it can be used to analyze the behavior of binary and ternary systems for caffeine and mefenamic acid formulations containing a starch-based disintegrant. The percolation threshold p(c) can be described by the volumetric ratio of the disintegrant to the drug substance being equal to p(c) = 0.2 (v/v) in in which both components have similar average particle sizes. In addition, the behavior of the disintegration time in the neighborhood of the percolation threshold can be mathematically modeled with the basic equation of the percolation theory yielding a critical exponent q = 0.28 +/- 0.06.
本研究的目的是根据渗流理论，针对一个真正的三元体系，研究关于最短崩解时间的玉米淀粉临界浓度的存在与否。本研究结果表明，渗流理论的应用并不局限于二元体系的研究。在这项工作中，展示了如何利用渗流理论来分析含有淀粉基崩解剂的咖啡因和甲芬那酸制剂的二元和三元体系的行为。渗流阈值p(c)可以用崩解剂与药物物质的体积比来描述，当两种组分具有相似的平均粒径时，p(c) = 0.2 (v/v)。此外，渗流阈值附近的崩解时间行为可以用渗流理论的基本方程进行数学建模，得到临界指数q = 0.28 +/- 0.06。
