Dahiya S, Pathak K
Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh, India.
Pharmazie. 2007 Apr;62(4):278-83.
An inclusion complex of hydroxypropyl beta-cyclodextrin (HPbetaCD), an amorphous, highly water soluble derivative and aceclofenac (AC), was prepared by the kneading method. The complex was further characterized by differential scanning calorimetry (DSC), X-ray powder diffractometry (XRD), fourier-transform infra red spectroscopy (FT-IR), scanning electron microscopy (SEM) and in vitro dissolution studies. The dissolution of AC from the inclusion complex studied by the dispersed powder technique showed significant dissolution enhancement in case of the kneaded product (KN) compared to pure AC. The complex possessed good compressibility and the tablets so compressed displayed good dissolution profile. The dissolution data were characterized by different model independent parameters such as dissolution efficiency (DE), difference factor (f1) and similarity factor (f2).
采用捏合方法制备了羟丙基-β-环糊精（HPβCD，一种无定形、高水溶性衍生物）与醋氯芬酸（AC）的包合物。通过差示扫描量热法（DSC）、X射线粉末衍射法（XRD）、傅里叶变换红外光谱法（FT-IR）、扫描电子显微镜（SEM）和体外溶出度研究对该包合物进行了进一步表征。通过分散粉末技术研究发现，与纯AC相比，捏合产物（KN）中AC从包合物中的溶出有显著增强。该包合物具有良好的可压性，压制的片剂显示出良好的溶出曲线。溶出数据通过不同的模型无关参数进行表征，如溶出效率（DE）、差异因子（f1）和相似因子（f2）。
