Poggio Carlo E
School of Dentistry, Istituto Stomatologico Italiano, Università degli Studi di Milano, Milan, Italy.
Clin Oral Implants Res. 2007 Aug;18(4):540-3. doi: 10.1111/j.1600-0501.2007.01361.x. Epub 2007 Apr 30.
The case report of a patient is presented who had been suffering from a plasmacytoma of the spine several years back, and who had developed a new plasmacytoma of the mandible, 3 years subsequent to the insertion of a dental implant. This second solitary lesion occurred 15 years after the first one, and without signs of conversion to multiple myeloma. Research in animal models has shown multinucleated giant cells, belonging to the monocyte-macrophage lineage, persisting between the titanium surface and the lymphohemopoietic compartment, at least 1.5 years after implant insertion. Factors that increase the proliferative activity of precursor B cells, for example a protracted macrophage activation, are likely to increase the risk of B cell oncogenesis. A possible role of the titanium surface in an increase of precursor B cell proliferative activity, thus facilitating a new localization, was evaluated.
本文报告了一名患者的病例，该患者几年前曾患有脊柱浆细胞瘤，在植入牙种植体3年后，下颌骨又出现了新的浆细胞瘤。这第二个孤立性病变发生在第一个病变出现15年后，且没有转化为多发性骨髓瘤的迹象。动物模型研究表明，属于单核细胞-巨噬细胞谱系的多核巨细胞在植入种植体后至少1.5年持续存在于钛表面和淋巴造血区之间。增加前体B细胞增殖活性的因素，例如长期的巨噬细胞激活，可能会增加B细胞肿瘤发生的风险。评估了钛表面在前体B细胞增殖活性增加从而促进新定位方面的可能作用。
