Zhao Yu, Wang Yuxia
Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Cell Mol Immunol. 2007 Apr;4(2):99-104.
5T4 oncotrophoblast glycoprotein is a transmembrane protein expressed on the embryonic tissue and various malignant tumor cell surfaces. It plays a vital role in the multiple biological and pathological processes including massive cellular migration during the embryogenesis, cell invasion associated with implantation, and neoplastic metastasis in the progression of tumorigenesis. Its restricted profile of expression stratifies criteria of tumor-associated antigen and makes it a new promising candidate for immunotherapy for cancer. Hence, illustrating this molecular function is necessary for discovering the principle of the tumor diffusion and aggravation and is helpful for developing novel and effective strategies of cancer therapy.
5T4癌滋养层糖蛋白是一种跨膜蛋白，在胚胎组织和各种恶性肿瘤细胞表面表达。它在多种生物学和病理过程中发挥着至关重要的作用，包括胚胎发育过程中的大量细胞迁移、与着床相关的细胞侵袭以及肿瘤发生发展过程中的肿瘤转移。其有限制的表达谱为肿瘤相关抗原的标准进行了分层，并使其成为癌症免疫治疗的一个新的有前景的候选者。因此，阐明这种分子功能对于发现肿瘤扩散和恶化的原理是必要的，并且有助于开发新的有效的癌症治疗策略。
