衰老对小鼠在免疫治疗后引发肿瘤消退能力的影响。
Effect of advanced ageing on the ability of mice to cause tumour regression in response to immunotherapy.
作者信息
Dunn P L, North R J
机构信息
Trudeau Institute, Saranac Lake, New York 12983.
出版信息
Immunology. 1991 Oct;74(2):355-9.
Abstract
The effect of ageing on tumour immunotherapy was investigated by comparing the ability of aged mice (20 months old) and young mice (3 months old) to cause regression of an established SA1 sarcoma in response to parenteral injection of endotoxin, or to sublethal, whole-body exposure to ionizing radiation. It was found that whereas treatment with either of these agents caused T-cell-dependent regression of the tumour in young mice, it failed to cause regression of the tumour in aged mice. The results are in keeping with extensive literature showing that ageing is associated with a decline in immune competence.
摘要
通过比较老年小鼠（20个月大）和年轻小鼠（3个月大）在经肠胃外注射内毒素或接受亚致死剂量全身电离辐射后，使已形成的SA1肉瘤消退的能力，研究了衰老对肿瘤免疫治疗的影响。结果发现，虽然用这两种试剂中的任何一种进行治疗都会使年轻小鼠的肿瘤发生T细胞依赖性消退，但在老年小鼠中却未能使肿瘤消退。这些结果与大量文献一致，表明衰老与免疫能力下降有关。
相似文献
1
Effect of advanced ageing on the ability of mice to cause tumour regression in response to immunotherapy.衰老对小鼠在免疫治疗后引发肿瘤消退能力的影响。
Immunology. 1991 Oct;74(2):355-9.
2
3
The antitumor function of tumor necrosis factor (TNF) II. Analysis of the role of endogenous TNF in endotoxin-induced hemorrhagic necrosis and regression of an established sarcoma.肿瘤坏死因子（TNF）的抗肿瘤功能II。内源性TNF在脂多糖诱导的出血性坏死及已形成肉瘤消退中作用的分析。
J Exp Med. 1988 Mar 1;167(3):1086-99. doi: 10.1084/jem.167.3.1086.
4
The therapeutic significance of concomitant antitumor immunity. II. Passive transfer of concomitant immunity with Ly-1+2- T cells primes established tumors in T cell-deficient recipients for endotoxin-induced regression.伴随抗肿瘤免疫的治疗意义。II. 用Ly-1+2- T细胞进行伴随免疫的被动转移可使T细胞缺陷受体中已形成的肿瘤对内毒素诱导的消退产生致敏。
Cancer Immunol Immunother. 1984;18(2):75-9. doi: 10.1007/BF00205737.
5
Interleukin 1-induced, T cell-mediated regression of immunogenic murine tumors. Requirement for an adequate level of already acquired host concomitant immunity.白细胞介素1诱导的、T细胞介导的免疫原性小鼠肿瘤消退。对已获得的宿主伴随免疫足够水平的需求。
J Exp Med. 1988 Dec 1;168(6):2031-43. doi: 10.1084/jem.168.6.2031.
6
A role for tumor necrosis factor in poly(I:C)-induced hemorrhagic necrosis and T-cell-dependent regression of a murine sarcoma.肿瘤坏死因子在聚肌胞苷酸诱导的小鼠肉瘤出血性坏死及T细胞依赖性消退中的作用。
J Interferon Res. 1991 Dec;11(6):333-40. doi: 10.1089/jir.1991.11.333.
7
8
Radiosensitive barrier to T-cell-mediated adoptive immunotherapy of established tumors.已形成肿瘤的T细胞介导的过继性免疫疗法的放射敏感屏障。
Cancer Res. 1990 Apr 15;50(8):2228-33.
9
The effects of cyclophosphamide and irradiation singly and in combination upon SaI growth in A/J mice.环磷酰胺和辐射单独及联合使用对A/J小鼠SaI生长的影响。
Am J Pathol. 1987 May;127(2):373-9.
10
The immunological basis of endotoxin-induced tumor regression. Requirement for T-cell-mediated immunity.内毒素诱导肿瘤消退的免疫学基础。T细胞介导的免疫的必要性。
J Exp Med. 1978 Dec 1;148(6):1550-9. doi: 10.1084/jem.148.6.1550.
引用本文的文献
1
Effects of aging on anticancer therapy in murine cancer models.衰老对小鼠癌症模型中抗癌治疗的影响。
Cancer Metastasis Rev. 2025 Aug 29;44(3):66. doi: 10.1007/s10555-025-10282-2.
2
Immunosenescence and cancer: molecular hallmarks, tumor microenvironment remodeling, and age-specific immunotherapy challenges.免疫衰老与癌症：分子特征、肿瘤微环境重塑及特定年龄的免疫治疗挑战
J Hematol Oncol. 2025 Aug 22;18(1):81. doi: 10.1186/s13045-025-01735-w.
本文引用的文献
1
Age influence on the immune system.年龄对免疫系统的影响。
Adv Immunol. 1980;29:287-330. doi: 10.1016/s0065-2776(08)60047-4.
2
Loss of tumor-specific and idiotype-specific immunity with age.随着年龄增长，肿瘤特异性和独特型特异性免疫力丧失。
J Exp Med. 1981 Aug 1;154(2):275-90. doi: 10.1084/jem.154.2.275.
3
Rescue of the tumor-specific immune response of aged mice in vitro.体外挽救衰老小鼠的肿瘤特异性免疫反应。
J Immunol. 1984 Jul;133(1):527-34.
4
Cell-mediated immunity in aged mice: an underlying lesion in IL 2 synthesis.衰老小鼠的细胞介导免疫：白细胞介素-2合成的潜在损伤。
J Immunol. 1982 May;128(5):2358-61.
5
Aging, idiotype repertoire shifts, and compartmentalization of the mucosal-associated lymphoid system.衰老、独特型库变化以及黏膜相关淋巴系统的区室化
Adv Immunol. 1984;36:143-88. doi: 10.1016/s0065-2776(08)60901-3.
6
The therapeutic significance of concomitant antitumor immunity. I. LY-1-2+ T cells from mice with a progressive tumor can cause regression of an established tumor in gamma-irradiated recipients.伴随抗肿瘤免疫的治疗意义。I. 患有进展性肿瘤的小鼠的LY-1⁺2⁺ T细胞可使经γ射线照射的受体小鼠体内已形成的肿瘤发生消退。
Cancer Immunol Immunother. 1984;18(2):69-74. doi: 10.1007/BF00205736.
7
Aging of natural and acquired immunity of mice. II. Decreased T cell responses to syngeneic tumor cells and parental-strain spleen cells.小鼠天然免疫和获得性免疫的衰老。II. T细胞对同基因肿瘤细胞和亲本品系脾细胞的反应降低。
Cancer Invest. 1983;1(2):139-49. doi: 10.3109/07357908309042416.
8
Lifespan and incidence of cancer and other diseases in selected long-lived inbred mice and their F 1 hybrids.特定长寿近交系小鼠及其F1杂种的寿命、癌症及其他疾病的发病率
J Natl Cancer Inst. 1973 May;50(5):1195-213. doi: 10.1093/jnci/50.5.1195.
9
The antitumor function of tumor necrosis factor (TNF) II. Analysis of the role of endogenous TNF in endotoxin-induced hemorrhagic necrosis and regression of an established sarcoma.肿瘤坏死因子（TNF）的抗肿瘤功能II。内源性TNF在脂多糖诱导的出血性坏死及已形成肉瘤消退中作用的分析。
J Exp Med. 1988 Mar 1;167(3):1086-99. doi: 10.1084/jem.167.3.1086.
10
Postirradiation recovery of lymphoid cells in the rat.大鼠淋巴样细胞的照射后恢复
Transplantation. 1988 Sep;46(3):418-25. doi: 10.1097/00007890-198809000-00018.
Zotero 插件