Dunn P L, North R J
Trudeau Institute, Saranac Lake, New York 12983.
Immunology. 1991 Oct;74(2):355-9.
The effect of ageing on tumour immunotherapy was investigated by comparing the ability of aged mice (20 months old) and young mice (3 months old) to cause regression of an established SA1 sarcoma in response to parenteral injection of endotoxin, or to sublethal, whole-body exposure to ionizing radiation. It was found that whereas treatment with either of these agents caused T-cell-dependent regression of the tumour in young mice, it failed to cause regression of the tumour in aged mice. The results are in keeping with extensive literature showing that ageing is associated with a decline in immune competence.
通过比较老年小鼠（20个月大）和年轻小鼠（3个月大）在经肠胃外注射内毒素或接受亚致死剂量全身电离辐射后，使已形成的SA1肉瘤消退的能力，研究了衰老对肿瘤免疫治疗的影响。结果发现，虽然用这两种试剂中的任何一种进行治疗都会使年轻小鼠的肿瘤发生T细胞依赖性消退，但在老年小鼠中却未能使肿瘤消退。这些结果与大量文献一致，表明衰老与免疫能力下降有关。
