睾丸的原位生殖细胞肿瘤、对侧睾丸活检与双侧睾丸癌
ITGCN of the testis, contralateral testicular biopsy and bilateral testicular cancer.
作者信息
Karellas Michael E, Damjanov Ivan, Holzbeierlein Jeffery M
机构信息
Department of Surgery, Division of Urology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.
出版信息
Urol Clin North Am. 2007 May;34(2):119-25; abstract vii. doi: 10.1016/j.ucl.2007.02.015.
Over 30 years ago Skakkebaek was the first to characterize a noninvasive precursor lesion (intratubular germ cell neoplasia or carcinoma in situ) that would progress to invasive testicular tumors. In this article we discuss the molecular changes thought to cause this malignant transformation, various conditions that predispose to the development of testicular germ cell tumors, diagnostic strategies, and treatment options. Additionally we discuss the current patterns of contralateral testicular biopsy to identify intratubular germ cell neoplasia, as well as the incidence and management of bilateral testicular tumors.
30多年前，斯卡克贝克首次对一种非侵袭性前驱病变（小管内生殖细胞瘤或原位癌）进行了特征描述，这种病变会发展为侵袭性睾丸肿瘤。在本文中，我们讨论了被认为导致这种恶性转化的分子变化、易患睾丸生殖细胞肿瘤的各种情况、诊断策略和治疗选择。此外，我们还讨论了目前对侧睾丸活检以识别小管内生殖细胞瘤的模式，以及双侧睾丸肿瘤的发病率和管理。
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