染色质数据库：酿酒酵母全基因组组蛋白修饰模式数据库。
ChromatinDB: a database of genome-wide histone modification patterns for Saccharomyces cerevisiae.
作者信息
O'Connor Timothy R, Wyrick John J
机构信息
School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA, USA.
出版信息
Bioinformatics. 2007 Jul 15;23(14):1828-30. doi: 10.1093/bioinformatics/btm236. Epub 2007 May 7.
UNLABELLED
Covalent modifications to histone proteins play a critical role in regulating gene transcription. Previous studies have used chromatin immunoprecipitation (ChIP) based microarray assays to profile genomic regions that are enriched or depleted for a particular histone modification. Such studies have been conducted extensively in the yeast Saccharomyces cerevisiae, but currently no comprehensive data repositories or analysis tools are available for these data sets. For this reason, we have developed the ChromatinDB database, which contains genome-wide ChIP data for 22 different histones or histone modifications in S. cerevisiae. ChromatinDB provides novel tools to facilitate the visualization and statistical analysis of chromatin features for user-selected gene sets.
AVAILABILITY
http://www.bioinformatics2.wsu.edu/ChromatinDB.
SUPPLEMENTARY INFORMATION
Supplementary data are available at Bioinformatics online.
未加标签
组蛋白的共价修饰在调节基因转录中起关键作用。先前的研究已使用基于染色质免疫沉淀（ChIP）的微阵列分析来描绘富含或缺乏特定组蛋白修饰的基因组区域。此类研究已在酿酒酵母中广泛开展，但目前尚无针对这些数据集的全面数据存储库或分析工具。因此，我们开发了ChromatinDB数据库，其中包含酿酒酵母中22种不同组蛋白或组蛋白修饰的全基因组ChIP数据。ChromatinDB提供了新颖的工具，以促进对用户选择的基因集的染色质特征进行可视化和统计分析。
可用性
http://www.bioinformatics2.wsu.edu/ChromatinDB。
补充信息
补充数据可在《生物信息学》在线获取。
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