Strand Arne H, Gudmundsdottir Helga, Fossum Eigil, Os Ingrid, Bjørnerheim Reidar, Kjeldsen Sverre E
Department of Cardiology, Ullevaal University Hospital, Oslo, Norway.
J Clin Hypertens (Greenwich). 2007 May;9(5):365-71. doi: 10.1111/j.1524-6175.2007.06479.x.
Left ventricular (LV) hypertrophy is related to blood pressure level and neurohormonal factors. The authors previously demonstrated that arterial norepinephrine levels predict LV mass in middle-aged men who developed hypertension through 20 years. The aim of this 20-year prospective study was to investigate arterial vasopressin, aldosterone, and renin as long-term predictors of LV mass. Normotensives (n=17), subjects who developed hypertension (n=17), and sustained hypertensives (n=22) were compared at baseline (42 years) and at follow-up (62 years). There were no significant differences in baseline vasopressin, aldosterone, or renin levels. The group with sustained hypertension had more LV hypertrophy (P=.025) at follow-up. Among new hypertensives, multiple regression analysis demonstrated that baseline arterial vasopressin (beta-0.53; P=.041) and aldosterone (beta-0.56;P=.032) independently explained LV mass index (R(2)=0.85; P=.035). In conclusion, baseline arterial vasopressin and aldosterone, but not renin, appear to predict LV mass in middle-aged men who developed hypertension over a 20-year period.
左心室（LV）肥厚与血压水平及神经激素因素有关。作者之前证明，动脉去甲肾上腺素水平可预测20年间患高血压的中年男性的左心室质量。这项为期20年的前瞻性研究的目的是调查动脉血管加压素、醛固酮和肾素作为左心室质量的长期预测指标。在基线（42岁）和随访（62岁）时，对血压正常者（n = 17）、患高血压者（n = 17）和持续性高血压患者（n = 22）进行了比较。基线时血管加压素、醛固酮或肾素水平无显著差异。持续性高血压组在随访时左心室肥厚更明显（P = 0.025）。在新患高血压者中，多元回归分析表明，基线动脉血管加压素（β = -0.53；P = 0.041）和醛固酮（β = -0.56；P = 0.032）可独立解释左心室质量指数（R² = 0.85；P = 0.035）。总之，基线动脉血管加压素和醛固酮而非肾素，似乎可预测20年间患高血压的中年男性的左心室质量。
