Fayol N, Labbé A, Dupont-Monod S, Dupas B, Baudouin C
Service d'Ophtalmologie III, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, USA.
J Fr Ophtalmol. 2007 Apr;30(4):348-56. doi: 10.1016/s0181-5512(07)89604-5.
To describe the appearance of various endothelial diseases with in vivo confocal microscopy and anterior chamber optical coherence tomography (AC OCT).
In this study, ten patients with five different corneal endothelial pathologies were evaluated. Three patients had cornea guttata, three had corneal endothelial precipitates, two had irido-corneo-endothelial (ICE) syndrome, one had endothelial folds, and one had breaks in the Descemet membrane. All patients had bilateral ophthalmologic examinations, in vivo confocal microscopy, and AC OCT analysis.
In cases of cornea guttata, AC OCT showed a finely embossed line corresponding to the empty intercellular cavities found with in vivo confocal microscopy. Corneal endothelium precipitates had the aspect of round formations suspended with the endothelium. Iris atrophy and irido-corneal synechiae resulting from ICE syndrome were precisely visualized with the AC OCT.
High-resolution images of the anterior segment could be obtained using the AC OCT. Associated with in vivo confocal microscopy, these two new imaging techniques provide a precise evaluation of endothelial pathologies.
利用活体共聚焦显微镜和前房光学相干断层扫描（AC OCT）描述各种内皮疾病的表现。
在本研究中，对10例患有5种不同角膜内皮病变的患者进行了评估。3例患有角膜滴状变性，3例有角膜内皮沉着物，2例有虹膜角膜内皮（ICE）综合征，1例有内皮褶皱，1例有后弹力层破裂。所有患者均接受了双眼眼科检查、活体共聚焦显微镜检查和AC OCT分析。
在角膜滴状变性病例中，AC OCT显示出一条精细的压纹线，与活体共聚焦显微镜检查发现的细胞间空泡相对应。角膜内皮沉着物表现为悬浮在内皮上的圆形结构。AC OCT可精确显示ICE综合征导致的虹膜萎缩和虹膜角膜粘连。
使用AC OCT可获得眼前节的高分辨率图像。这两种新的成像技术与活体共聚焦显微镜相结合，可对内皮病变进行精确评估。
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