Sakkers R J, de Jong D, van der Heul R O
University Hospital Leiden, The Netherlands.
J Bone Joint Surg Am. 1991 Dec;73(10):1532-6.
We performed a histological examination and DNA analysis on samples of tissue from a forty-seven-year-old woman who had a clinical diagnosis of pigmented villonodular synovitis. The histological examination confirmed the diagnosis. The evaluation of the samples of tissue with preferential X-chromosome inactivation analysis (a molecular biological method for the study of clonality in tumors) showed that the lesion was polyclonal in origin. We concluded, therefore, that pigmented villonodular synovitis is more likely to be a reactive process than a true neoplasm.
我们对一名临床诊断为色素沉着绒毛结节性滑膜炎的47岁女性的组织样本进行了组织学检查和DNA分析。组织学检查证实了诊断。采用优先X染色体失活分析（一种研究肿瘤克隆性的分子生物学方法）对组织样本进行评估，结果显示该病变起源于多克隆。因此，我们得出结论，色素沉着绒毛结节性滑膜炎更可能是一种反应性过程，而非真正的肿瘤。
