McMullen Nichole M, Pasumarthi Kishore B S
Department of Pharmacology, Sir Charles Tupper Medical Building, Dalhousie University, Halifax, Canada.
Can J Physiol Pharmacol. 2007 Jan;85(1):1-15. doi: 10.1139/Y06-105.
Heart failure secondary to ischemic heart disease, hypertension, and myocardial infarction is a common cause of death in developed countries. Although pharmacological therapies are very effective, poor prognosis and shorter life expectancy of heart disease patients clearly indicate the need for alternative interventions to complement the present therapies. Since the progression of heart disease is associated with the loss of myocardial cells, the concept of donor cell transplantation into host myocardium is emerging as an attractive strategy to repopulate the damaged tissue. To this end, a number of donor cell types have been tested for their ability to increase the systolic function of diseased hearts in both experimental and clinical settings. Although initial clinical trials with bone marrow stem cells are encouraging, long-term consequences of such interventions are yet to be rigorously examined. While additional laboratory studies are required to address several issues in this field, there is also a clear need for further characterization of drug interactions with donor cells in these interventions. Here, we provide a brief summary of current pharmacological and cell-based therapies for heart disease. Further, we discuss the potential of various donor cell types in myocardial repair, mechanisms underlying functional improvement in cell-based therapies, as well as potential interactions between pharmacological and cell-based therapies.
继发于缺血性心脏病、高血压和心肌梗死的心力衰竭是发达国家常见的死亡原因。尽管药物治疗非常有效，但心脏病患者预后不佳且预期寿命较短，这清楚地表明需要替代干预措施来补充现有治疗方法。由于心脏病的进展与心肌细胞的丧失有关，将供体细胞移植到宿主心肌中的概念正成为一种有吸引力的策略，用于修复受损组织。为此，已经在实验和临床环境中测试了多种供体细胞类型增加患病心脏收缩功能的能力。尽管骨髓干细胞的初步临床试验令人鼓舞，但此类干预的长期后果仍有待严格审查。虽然需要更多的实验室研究来解决该领域的几个问题，但在这些干预措施中，也显然需要进一步表征药物与供体细胞的相互作用。在此，我们简要总结了目前用于治疗心脏病的药物疗法和基于细胞的疗法。此外，我们讨论了各种供体细胞类型在心肌修复中的潜力、基于细胞的疗法中功能改善的潜在机制，以及药物疗法和基于细胞的疗法之间的潜在相互作用。
