Azar Zeina M, Mehdi Mohamad Z, Srivastava Ashok K
Montreal Diabetes Research Centre, Centre hospitalier de l'Université de Montréal (CHUM)- Angus Campus and Department of Medicine, Université de Montréal, 2901, Rachel East, Montreal, QC H1W 4A4, Canada.
Can J Physiol Pharmacol. 2007 Jan;85(1):105-11. doi: 10.1139/Y06-101.
Transactivation of epidermal growth factor receptor (EGFR) is a well-documented mechanism by which vasoactive peptides and H2O2 elicit their cellular responses. However, a role for the insulin-like growth factor type-1 receptor (IGF-1R) transactivation in mediating the effects of angiotensin II (Ang II) and H2O2 in vascular smooth muscle cells from different artery types have also been recently recognized. By using a series of pharmacological inhibitors of various growth factor receptor tyrosine kinases and a direct analysis of the phosphorylation status of the beta-subunit of IGF-1R, a requirement of this growth factor receptor in Ang II and H2O2 response has been demonstrated. This review discusses some of the studies that highlight the importance of IGF-1R transactivation in mediating Ang II- and H2O2-induced mitogen-activated protein kinase and protein kinase B signaling pathways.
表皮生长因子受体（EGFR）的反式激活是一种有充分文献记载的机制，血管活性肽和过氧化氢通过该机制引发细胞反应。然而，胰岛素样生长因子1型受体（IGF-1R）反式激活在介导不同动脉类型血管平滑肌细胞中血管紧张素II（Ang II）和过氧化氢的作用方面所起的作用，最近也已得到认可。通过使用一系列针对各种生长因子受体酪氨酸激酶的药理学抑制剂，并直接分析IGF-1Rβ亚基的磷酸化状态，已证明这种生长因子受体在Ang II和过氧化氢反应中的必要性。本综述讨论了一些突出IGF-1R反式激活在介导Ang II和过氧化氢诱导的丝裂原活化蛋白激酶和蛋白激酶B信号通路中的重要性的研究。
