Mukai Masaya, Nakamura Masato, Kishima Kyoko, Ninomiya Hiromi, Nomura Nozomi, Sato Hisayoshi, Kato Nobuaki, Machida Tomohisa, Nakasaki Hisao, Makuuchi Hiroyasu
Department of Surgery, Tokai University Hachioji Hospital, Hachioji, Tokyo 192-0032, Japan.
Oncol Rep. 2007 Jun;17(6):1365-9.
This study was designed to examine the relationship between occult neoplastic cells (ONCs) inside and outside harvested lymph nodes (intranodal/extranodal ONCs) and local recurrence in 30 patients who underwent curative resection of primary colorectal cancer. Among 10 patients with colon cancer (Dukes' A=1, Dukes' B=6 and Dukes' C=3), intranodal ONCs were positive in 1 patient (10.0%) and negative in 9 patients (90.0%), while extranodal ONCs were negative in all 10 patients (100.0%). There were no significant differences between the detection of intranodal or extranodal ONCs. Among 20 patients with rectal cancer (Dukes' A=4, Dukes' B=2 and Dukes' C=14), intranodal ONCs were positive in 5 (25.0%) and negative in 15 (75.0%), while extranodal ONCs were positive in 3 (15.0%) and negative in 17 (85.0%). There were no significant differences between the detection of intranodal or extranodal ONCs. These results suggest that patients with rectal cancer and extranodal ONCs should be followed-up carefully as a high-risk group for pelvic local recurrence. However, the prevalence of extranodal and intranodal ONCs was almost similar.
本研究旨在检测30例行原发性结直肠癌根治性切除术患者的 harvested 淋巴结内外隐匿性肿瘤细胞（ONCs）（结内/结外ONCs）与局部复发之间的关系。在10例结肠癌患者中（杜克A期=1例，杜克B期=6例，杜克C期=3例），1例患者（10.0%）的结内ONCs呈阳性，9例患者（90.0%）呈阴性，而所有10例患者（100.0%）的结外ONCs均为阴性。结内或结外ONCs的检测之间无显著差异。在20例直肠癌患者中（杜克A期=4例，杜克B期=2例，杜克C期=14例），5例（25.0%）的结内ONCs呈阳性，15例（75.0%）呈阴性，而3例（15.0%）的结外ONCs呈阳性，17例（85.0%）呈阴性。结内或结外ONCs的检测之间无显著差异。这些结果表明，直肠癌和结外ONCs患者作为盆腔局部复发的高危人群应进行仔细随访。然而，结外和结内ONCs的发生率几乎相似。 （注：“harvested”这里可能有误，推测可能是“切除的”之类意思，但按原文翻译为“收获的”不太符合语境，需结合更准确原文确认。）
