Samal K K, Sahu C S, Nanda R C
Department of Medicine, VSS Medical College, Burla.
J Indian Med Assoc. 1991 Jun;89(6):155-7.
To determine whether diabetes mellitus alters the function of platelets, a study on platelet adhesiveness in 30 controls and 75 newly diagnosed diabetics (25 cases of type-1 and 50 cases of type-II) before and after treatment was undertaken. The platelet adhesiveness was 68.83 +/- 6.09% (mean + SD) in type-I diabetics, 72.43 +/- 6.10% in type-II diabetics and 56.31 +/- 9.62% in controls (p less than 0.001 for all comparisons). In complicated diabetics (54 cases) the platelet adhesiveness was 72.33 +/- 5.99% and in uncomplicated diabetics (21 cases) it was 67.33 +/- 5.82% (p less than 0.05). Platelet adhesiveness was significantly reduced after treatment (with insulin it was 62.12 +/- 7.46%, with phenformin 62.10 +/- 8.63 and with tolbutamide 67.12 +/- 7.97%) when compared with pretreatment values. Platelet adhesiveness had no significant correlation with blood sugar and serum cholesterol levels. These results support the concept that platelet adhesiveness is high in diabetes mellitus and is reduced with control of diabetic state after treatment.
为了确定糖尿病是否会改变血小板的功能，我们对30名对照组和75名新诊断的糖尿病患者（25例1型和50例2型）治疗前后的血小板黏附性进行了研究。1型糖尿病患者的血小板黏附性为68.83±6.09%（均值±标准差），2型糖尿病患者为72.43±6.10%，对照组为56.31±9.62%（所有比较的p值均小于0.001）。在合并症糖尿病患者（54例）中，血小板黏附性为72.33±5.99%，在无合并症糖尿病患者（21例）中为67.33±5.82%（p值小于0.05）。与治疗前的值相比，治疗后血小板黏附性显著降低（胰岛素治疗后为62.12±7.46%，苯乙双胍治疗后为62.10±8.63%，甲苯磺丁脲治疗后为67.12±7.97%）。血小板黏附性与血糖和血清胆固醇水平无显著相关性。这些结果支持了这样一种观点，即糖尿病患者的血小板黏附性较高，治疗后随着糖尿病状态的控制而降低。
