在危重症儿童应用普通肝素治疗中，肝素剂量与标准临床监测指标之间缺乏相关性。
Lack of correlation between heparin dose and standard clinical monitoring tests in treatment with unfractionated heparin in critically ill children.
作者信息
Kuhle Stefan, Eulmesekian Pablo, Kavanagh Brian, Massicotte Patricia, Vegh Patsy, Lau Alice, Mitchell Lesley G
机构信息
Division of Haematology/Oncology, Department of Population Health Sciences, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
出版信息
Haematologica. 2007 Apr;92(4):554-7. doi: 10.3324/haematol.10696.
UNLABELLED
The activated partial thromboplastin time (aPTT) and anti-Xa activity are used for monitoring unfractionated heparin (UFH) therapy in children and may not be optimal.
OBJECTIVE
Determine correlations of aPTT, anti-Xa and UFH dose in children. Single centre prospective cohort study in children receiving UFH. The aPTT and anti-Xa results from routine coagulation monitoring were collected. Thirty-nine children (median age 18 days) were enrolled. There was no relationship between aPTT and UFH dose (r2=0.12) or anti-Xa and UFH dose (r2=0.03) or aPTT and anti-Xa (r2=0.22). aPTT and anti-Xa do not accurately monitor UFH therapy in children.
未标注
活化部分凝血活酶时间（aPTT）和抗Xa活性用于监测儿童普通肝素（UFH）治疗，但可能并非最佳选择。
目的
确定儿童aPTT、抗Xa与UFH剂量之间的相关性。对接受UFH治疗的儿童进行单中心前瞻性队列研究。收集常规凝血监测的aPTT和抗Xa结果。纳入39名儿童（中位年龄18天）。aPTT与UFH剂量（r2 = 0.12）、抗Xa与UFH剂量（r2 = 0.03）或aPTT与抗Xa（r2 = 0.22）之间均无相关性。aPTT和抗Xa不能准确监测儿童的UFH治疗。
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