Dorner Daniela, Gotzmann Josef, Foisner Roland
Department of Medical Biochemistry, Max F. Perutz Laboratories, Medical University of Vienna, Dr. Bohrgasse 9/3, A-1030 Vienna, Austria.
FEBS J. 2007 Mar;274(6):1362-73. doi: 10.1111/j.1742-4658.2007.05695.x.
Lamins are major structural components of the nuclear envelope in multicellular eukaryotes. Particularly A-type lamins are also located in the nucleoplasm, likely involving a specific binding partner, lamina-associated polypeptide 2alpha (LAP2alpha). LAP2alpha-lamins A/C complexes in the nucleoplasm have been implicated in the regulation of gene expression by various means. They bind chromatin proteins and chromatin modifying enzymes, and can thus participate in epigenetic control pathways. Furthermore, binding of lamins A/C complexes to specific transcription factors and repressors may directly affect their transcriptional activity. LAP2alpha-lamins A/C also regulate retinoblastoma protein and influence cell cycle progression and differentiation, which could have important implications for molecular mechanisms of laminopathic diseases, linked to lamins A/C mutations.
核纤层蛋白是多细胞真核生物核膜的主要结构成分。特别是A型核纤层蛋白也存在于核质中，可能涉及一个特定的结合伴侣，即核纤层相关多肽2α（LAP2α）。核质中的LAP2α-核纤层蛋白A/C复合物已被认为通过多种方式参与基因表达的调控。它们与染色质蛋白和染色质修饰酶结合，因此可以参与表观遗传控制途径。此外，核纤层蛋白A/C复合物与特定转录因子和阻遏物的结合可能直接影响它们的转录活性。LAP2α-核纤层蛋白A/C还调节视网膜母细胞瘤蛋白，并影响细胞周期进程和分化，这可能对与核纤层蛋白A/C突变相关的核纤层蛋白病的分子机制具有重要意义。
