Schnackenberg Laura K
National Center for Toxicological Research, Division of Systems Toxicology, US Food & Drug Administration, Jefferson, AR 72079-9502, USA.
Expert Rev Mol Diagn. 2007 May;7(3):247-59. doi: 10.1586/14737159.7.3.247.
Systems biology attempts to elucidate the complex interaction between genes, proteins and metabolites to provide a mechanistic understanding of cellular function and how this function is affected by disease processes, drug toxicity or drug efficacy effects. Global metabolic profiling is an important component of systems biology that can be applied in both preclinical and clinical settings for drug discovery and development, and to study disease mechanisms. The metabolic profile encodes the phenotype, which is composed of the genotype and environmental factors. The phenotypic profile can be used to make decisions about the best course of treatment for an individual patient. Understanding the combined effects of genetics and environment through a systems biology framework will enable the advancement of personalized medicine.
系统生物学试图阐明基因、蛋白质和代谢物之间的复杂相互作用，以便从机制上理解细胞功能以及该功能如何受到疾病过程、药物毒性或药物疗效的影响。整体代谢谱分析是系统生物学的一个重要组成部分，可应用于临床前和临床环境，用于药物发现与开发以及研究疾病机制。代谢谱编码表型，表型由基因型和环境因素组成。表型谱可用于为个体患者选择最佳治疗方案。通过系统生物学框架了解遗传和环境的综合作用将推动个性化医疗的发展。
