Berto M C, Filha S C, Camelier A, Rosa F W, de Souza Bulle Oliveira A, Jardim J R
Respiratory and Neurology Divisions, UNIFESP, Federal University of São Paulo, São Paulo, Brazil.
Acta Neurol Scand. 2007 May;115(5):301-5. doi: 10.1111/j.1600-0404.2007.00643.x.
This study investigated whether aminophylline has an acute effect on the muscle performance of patients with amyotrophic lateral sclerosis (ALS). The study was a randomized, double-blind, crossover against placebo.
Twenty-five patients (48.5 +/- 14.1 years) with ALS were evaluated by means of forced vital capacity (FVC), maximal mouth inspiratory and expiratory pressures (P(Imax)/P(Emax)) and endurance, maximum voluntary ventilation (MVV) and handgrip strength (HS); variables were measured before and after the patients received an intravenous infusion of aminophylline or placebo.
MVV (P<0.02) and HS of the right and left hands (P=0.05) increased after aminophylline infusion. There was a positive correlation between FVC and P(Imax) (r=0.80; P<0.05); between MVV and P(Imax) post-aminophylline, respectively (r=0.77; P<0.05). Serum aminophylline levels ranged from 5.3 to 10.5 microg/mL (mean 7.30).
The acute administration of aminophylline improves the endurance of respiratory muscles and increases handgrip strength in patients with ALS.
本研究调查氨茶碱对肌萎缩侧索硬化症（ALS）患者肌肉功能是否有急性影响。该研究为一项针对安慰剂的随机、双盲、交叉试验。
通过用力肺活量（FVC）、最大口腔吸气和呼气压力（P(Imax)/P(Emax)）以及耐力、最大自主通气量（MVV）和握力（HS）对25例ALS患者（48.5±14.1岁）进行评估；在患者接受氨茶碱或安慰剂静脉输注前后测量各项变量。
输注氨茶碱后，MVV（P<0.02）以及右手和左手的HS（P=0.05）增加。FVC与P(Imax)之间存在正相关（r=0.80；P<0.05）；氨茶碱输注后MVV与P(Imax)之间也分别存在正相关（r=0.77；P<0.05）。血清氨茶碱水平范围为5.3至10.5微克/毫升（平均7.30）。
急性给予氨茶碱可改善ALS患者呼吸肌的耐力并增加握力。
