Cheng Cheng-I, Wu Chiung-Jen, Hsieh Yuan-Kai, Chen Yen-Hsun, Chen Chien-Jen, Chen Shyh-Ming, Yang Cheng-Hsu, Hung Wei-Chin, Yip Hon-Kan, Chen Mien-Cheng, Fu Morgan, Fang Chih-Yuan
The Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC.
Int J Cardiol. 2008 May 23;126(2):177-82. doi: 10.1016/j.ijcard.2007.03.125. Epub 2007 May 8.
Although catheter-induced left main coronary artery (LMCA) dissection is a rare complication of coronary catheterization, it is a common cause of periprocedural mortality. Emergent coronary artery bypass surgery (CABG) is the mainstay for managing this acute complication. However, hemodynamic deterioration may progress while patients await emergent CABG; consequently, a high postoperative mortality rate has been reported. Although the number of cases was small, prompt bail-out stenting for iatrogenic LMCA dissection had reportedly reversed this complication with favorable clinical outcomes.
This study included 13 cases of attempted stenting for iatrogenic LMCA dissection classified as grades C-F based on the National Heart, Lung and Blood Institute (NHLBI) classification system. Angiographic success, in-hospital mortality and long-term outcomes were analyzed.
The incidence of iatrogenic LM dissection was 0.071%. Most of the patients were initially asymptomatic. Angiographic success was achieved in 11 of 13 patients (84.6%). Including one patient who underwent emergent CABG after a failed wiring attempt, two mortalities occurred in this series. Mean follow-up duration of the ten patients discharged was 30.1+/-11.8 months, and no cardiac deaths occurred. Follow-up angiogram of eight patients with a mean interval of 5.2+/-2.3 months after initial event demonstrated restenosis in three patients occurring either at the ostiums of the left anterior descending artery or left circumflex artery. Revascularization was performed on two patients.
Successful bail-out stenting resulted in good long-term survival and should be considered for initial management of iatrogenic LMCA dissection.
尽管导管所致左主干冠状动脉(LMCA)夹层是冠状动脉导管插入术的一种罕见并发症,但它是围手术期死亡的常见原因。急诊冠状动脉旁路移植术(CABG)是处理这种急性并发症的主要方法。然而,在患者等待急诊CABG时,血流动力学恶化可能会进展;因此,据报道术后死亡率很高。尽管病例数量较少,但据报道,对医源性LMCA夹层进行及时的补救性支架置入术可逆转这一并发症,并取得良好的临床结果。
本研究纳入了13例根据美国国立心肺血液研究所(NHLBI)分类系统分类为C-F级的医源性LMCA夹层的补救性支架置入术病例。分析了血管造影成功率、住院死亡率和长期预后。
医源性左主干夹层的发生率为0.071%。大多数患者最初无症状。13例患者中有11例(84.6%)血管造影成功。包括1例在导线置入尝试失败后接受急诊CABG的患者,本系列中有2例死亡。10例出院患者的平均随访时间为30.1±11.8个月,无心脏死亡发生。8例患者在初始事件后平均5.2±2.3个月进行随访血管造影,结果显示3例患者在左前降支或左旋支开口处发生再狭窄。2例患者进行了血运重建。
成功的补救性支架置入术可带来良好的长期生存,应考虑将其作为医源性LMCA夹层初始治疗的方法。