Guo Sheng-Zhen, Huang Ke, Shi Yong-Yong, Tang Wei, Zhou Jian, Feng Guo-Yin, Zhu Shao-Min, Liu Hui-Jun, Chen Yi, Sun Xiao-Dong, He Lin
Bio-X Center, Shanghai Jiao Tong University, Shanghai 200030, PR China.
Schizophr Res. 2007 Jul;93(1-3):385-90. doi: 10.1016/j.schres.2007.03.007. Epub 2007 May 9.
The glutamatergic dysfunction hypothesis of schizophrenia implicates the genes involved in glutamatergic transmission as strong candidates for schizophrenia-susceptibility. Recent linkage and association studies have identified the glutamate receptor, ionotropic, delta 1 gene GRID1 on 10q22 as a strong candidate for schizophrenia. In this current association study, we genotyped five genetic variants within the GRID1 gene in 567 Chinese Han subjects recruited from Northeast of China (260 schizophrenics and 307 normal controls). Four SNPs, rs1902666 (P=0.024), rs2814351 (P=0.027), rs11591408 (P=0.0000107) and rs999383 (P=0.000093) were found to be significantly associated with schizophrenia. Haplotype analysis also revealed significance with global P values of 0.0081 and 0.00076 for SNPs 1-2 and SNPs 3-4-5 haplotypes, respectively. Our results strongly support previously reported association studies, implicating GRID1 in the etiology of schizophrenia.
精神分裂症的谷氨酸能功能障碍假说认为，参与谷氨酸能传递的基因是精神分裂症易感性的有力候选基因。最近的连锁和关联研究已将位于10q22的离子型谷氨酸受体δ1基因GRID1确定为精神分裂症的一个有力候选基因。在这项当前的关联研究中，我们对从中国东北地区招募的567名中国汉族受试者（260名精神分裂症患者和307名正常对照）的GRID1基因内的五个遗传变异进行了基因分型。发现四个单核苷酸多态性（SNP），即rs1902666（P = 0.024）、rs2814351（P = 0.027）、rs11591408（P = 0.0000107）和rs999383（P = 0.000093）与精神分裂症显著相关。单倍型分析也显示出显著性，SNP 1 - 2和SNP 3 - 4 - 5单倍型的全局P值分别为0.0081和0.00076。我们的结果有力地支持了先前报道的关联研究，表明GRID1与精神分裂症的病因有关。
