Wisco Jonathan J, Kuperberg Gina, Manoach Dara, Quinn Brian T, Busa Evelina, Fischl Bruce, Heckers Stephan, Sorensen A Gregory
MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Building 149 13th Street, Room 2301, Charlestown, MA 02129, United States.
Schizophr Res. 2007 Aug;94(1-3):317-27. doi: 10.1016/j.schres.2007.03.031. Epub 2007 May 9.
We compared cortical folding patterns between patients with schizophrenia and demographically-matched healthy controls in prefrontal and temporal regions of interest. Using the Freesurfer (http://surfer.nmr.mgh.harvard.edu) cortical surface-based reconstruction methodology, we indirectly ascertained cortical displacement and convolution, together, by measuring the degree of metric distortion required to optimally register cortical folding patterns to an average template. An area within the pars triangularis of the left inferior frontal gyrus (Broca's area) showed significantly reduced metric distortion in the patient group relative to the control group (p=0.0352). We discuss these findings in relation to the neurodevelopmental hypothesis and language dysfunction in schizophrenia.
我们比较了精神分裂症患者与人口统计学匹配的健康对照者在前额叶和颞叶感兴趣区域的皮质折叠模式。使用基于Freesurfer(http://surfer.nmr.mgh.harvard.edu)皮质表面的重建方法,我们通过测量将皮质折叠模式最佳配准到平均模板所需的度量失真程度,间接确定了皮质位移和卷曲。相对于对照组,左侧额下回三角部(布罗卡区)内的一个区域在患者组中显示出明显降低的度量失真(p = 0.0352)。我们结合神经发育假说和精神分裂症中的语言功能障碍来讨论这些发现。