脐带血细胞在糖尿病治疗中的应用。
The application of umbilical cord blood cells in the treatment of diabetes mellitus.
作者信息
Koblas Tomas, Harman S Mitchell, Saudek Frantisek
机构信息
Laboratory of Pancreatic Islets, Institute for Clinical and Experimental Medicine, Center for Cell Therapy and Tissue Repair, Prague, Czech Republic.
出版信息
Rev Diabet Stud. 2005 Winter;2(4):228-34. doi: 10.1900/RDS.2005.2.228. Epub 2006 Feb 10.
In recent years, human umbilical cord blood (HUCB) has emerged as an attractive tool for cell-based therapy. Although at present the clinical application of HUCB is limited to the fields of hematology and oncology, a rising number of studies show potential for further application in the treatment of non-hematopoietic diseases. HUCB, with its real abundance, simple collection procedure and no serious ethical dilemmas, represents a valuable alternative to the use of other stem cell sources. The aim of this article is to review the literature on HUCB and to assess its eventual usability in the treatment of diabetes mellitus. This review presents some recent reports concerning pancreatic endocrine stem cells and their identification, HUCB stem cells and their advantages and, finally, the potential for converting HUCB-derived stem cells into insulin-producing beta-cells.
近年来，人脐带血（HUCB）已成为一种颇具吸引力的细胞治疗工具。尽管目前HUCB的临床应用仅限于血液学和肿瘤学领域，但越来越多的研究表明其在治疗非血液系统疾病方面具有进一步应用的潜力。HUCB来源丰富、采集程序简单且不存在严重的伦理困境，是使用其他干细胞来源的一种有价值的替代选择。本文旨在综述关于HUCB的文献，并评估其在糖尿病治疗中的最终可用性。本综述介绍了一些关于胰腺内分泌干细胞及其鉴定、HUCB干细胞及其优势的近期报道，最后还介绍了将HUCB来源的干细胞转化为产生胰岛素的β细胞的潜力。
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