Karlsson Gudjon, Rehman Jalees, Kalaria Vijay, Breall Jeffrey A
Cardiac Catheterization Laboratories, Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
Catheter Cardiovasc Interv. 2007 Jun 1;69(7):955-8. doi: 10.1002/ccd.21151.
Coronary stent thrombosis is a rare occurrence in the era of dual-antiplatelet therapy. It is not known whether patients who use cocaine have a higher risk of thrombosis following coronary stent placement.
We studied 247 consecutive patients who underwent coronary stent placement at an inner-city hospital.
Twelve patients (4.9%) were actively using cocaine at the time of PCI. Of these twelve patients, four patients presented with stent thrombosis (33%) at a mean of 51 +/- 40 days (median 45 days), after the index revascularization procedure. Only 2 of the 235 patients without documented cocaine use (0.85%) had stent thrombosis during the same period (P < 0.0001).
The patients who actively use cocaine have a markedly higher risk of stent thrombosis when compared with patients without a documented history of cocaine use. We discuss various factors that potentially predispose cocaine users to stent thrombosis.
在双联抗血小板治疗时代，冠状动脉支架血栓形成是一种罕见的情况。目前尚不清楚使用可卡因的患者在冠状动脉支架置入后是否有更高的血栓形成风险。
我们研究了一家市中心医院连续接受冠状动脉支架置入的247例患者。
12例患者（4.9%）在PCI时正在积极使用可卡因。在这12例患者中，4例患者（33%）在首次血运重建术后平均51±40天（中位数45天）出现支架血栓形成。在同期，235例无可卡因使用记录的患者中只有2例（0.85%）发生支架血栓形成（P<0.0001）。
与无可卡因使用记录的患者相比，积极使用可卡因的患者发生支架血栓形成的风险明显更高。我们讨论了可能使可卡因使用者易发生支架血栓形成的各种因素。
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