Hayes Keith C
The University of Western Ontario, Department of Physical Medicine & Rehabilitation, London, Ontario, Canada.
Expert Rev Neurother. 2007 May;7(5):453-61. doi: 10.1586/14737175.7.5.453.
Fampridine-SR is a sustained-release tablet form of the K(+) channel-blocking compound 4-aminopyridine that has been shown to restore conduction in focally demyelinated axons, to enhance synaptic transmission in many types of neurons and to potentiate muscle contraction. The present review describes the mechanism of action and chemistry of Fampridine-SR, its pharmacokinetics and safety, and the outcomes of clinical trials of its safety and efficacy for enhancing neuromuscular function in patients with multiple sclerosis or spinal cord injury. Randomized clinical trials completed to date indicate that this form of K(+) channel blockade may be useful for the improvement of walking ability in patients with multiple sclerosis.
缓释氨吡啶是钾离子通道阻滞剂4-氨基吡啶的缓释片剂形式，已被证明可恢复局灶性脱髓鞘轴突的传导，增强多种类型神经元的突触传递，并增强肌肉收缩。本综述描述了缓释氨吡啶的作用机制、化学性质、药代动力学和安全性，以及其在改善多发性硬化症或脊髓损伤患者神经肌肉功能方面的安全性和疗效的临床试验结果。迄今为止完成的随机临床试验表明，这种钾离子通道阻滞形式可能有助于改善多发性硬化症患者的行走能力。
