Reissmann S, Paegelov I, Leisner H, Arold H
Experientia. 1975 Dec 15;31(12):1395-6. doi: 10.1007/BF01923205.
Some analogues of bradykinin, especially with replacements by other amino acids of phenylalanine in position 8, have been investigated for enzymatic stability against kininase II from rat duodenum microsomes and rat uterus plasma membranes, respectively. As compared with bradykinin, two of the analogues, [8-erythro-beta-phenylserine]- and [8-erythro-alpha-Amino-beta-phenylbutyric acid]-Bradykinin were stable to enzymatic degradation. Therefore, the latter may be used for studies in hormone-receptor interaction.
已分别研究了一些缓激肽类似物，尤其是8位苯丙氨酸被其他氨基酸取代的类似物，对来自大鼠十二指肠微粒体和大鼠子宫质膜的激肽酶II的酶稳定性。与缓激肽相比，两种类似物，[8-赤藓糖-β-苯丝氨酸]-和[8-赤藓糖-α-氨基-β-苯丁酸]-缓激肽对酶促降解具有稳定性。因此，后者可用于激素-受体相互作用的研究。
