Tang Xue-Feng, Zhang Wen-Yan, Li Gan-di, Jiang Li-Li, Liu Wei-Ping
Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhonghua Bing Li Xue Za Zhi. 2007 Feb;36(2):98-101.
To study the clinicopathologic features and differential diagnosis of splenic lymphangioma.
Eighteen cases of splenic lymphangioma were retrieved from the pathology archives during the period between January 1990 to December 2005. The clinicopathologic features were analyzed. Immunohistochemical study was performed on the paraffin sections of 16 cases.
The age of the patients ranged from 9 to 72 years (median = 40 years). Thirteen patients were males and 5 were females. Clinically, the tumor could be asymptomatic or present with abdominal symptoms and hypersplenism. Follow-up information was available in 13 patients (72.2%) and the duration varied from 5 months to 15 years. All 13 patients had an uneventful clinical course, with no evidence of residual disease, local recurrence or metastasis. Gross examination showed splenic enlargement. The tumor appeared as cystic (8/18), solid (5/18) or honeycomb mass (5/18), either solitary (5/18) or multifocal (13/18). Histologically, splenic lymphangioma could be subclassified as cavernous (9/18), cystic (5/18) or mixed (4/18). Immunohistochemical study showed that the positivity rates for CD9 and D2-40 were 100% and 43.8% respectively.
Splenic lymphangioma is a rarely encountered entity that can be misdiagnosed as a splenic hemangioma. A definite diagnosis depends on pathologic examination.
研究脾淋巴管瘤的临床病理特征及鉴别诊断。
回顾性分析1990年1月至2005年12月间病理档案中的18例脾淋巴管瘤病例，分析其临床病理特征，并对其中16例石蜡切片进行免疫组化研究。
患者年龄9至72岁（中位年龄40岁），男性13例，女性5例。临床上，肿瘤可无症状，或表现为腹部症状及脾功能亢进。13例患者（72.2%）有随访资料，随访时间5个月至15年不等。所有13例患者临床过程平稳，无残留病灶、局部复发或转移迹象。大体检查显示脾脏肿大。肿瘤表现为囊性（8/18）、实性（5/18）或蜂窝状肿块（5/18），单发（5/18）或多发（13/18）。组织学上，脾淋巴管瘤可分为海绵状（9/18）、囊性（5/18）或混合型（4/18）。免疫组化研究显示，CD9和D2-40阳性率分别为100%和43.8%。
脾淋巴管瘤是一种罕见疾病，易误诊为脾血管瘤。明确诊断依赖于病理检查。
