Reed Danielle R, Bachmanov Alexander A, Tordoff Michael G
Monell Chemical Senses Center, Philadelphia, PA 19104, USA.
Physiol Behav. 2007 Aug 15;91(5):593-600. doi: 10.1016/j.physbeh.2007.03.026. Epub 2007 Apr 1.
We measured body weight and composition of approximately 10 male and approximately 10 female mice from 40 inbred strains. Body composition was assessed in approximately 16-wk old mice that had been individually housed and fed a high-carbohydrate, low-fat diet (AIN-76A) for the previous 8 wk. Carcass lean and fat weights were assessed using a PIXIMus II DEXA and confirmed by fat extraction assay. There was a nearly continuous range of body weights, from a strain mean+/-SE of 11.4+/-0.2 g (MSM/MsJ) to 39.3+/-1.8 g (NON/LtJ). The percentage of body weight that was fat (%Fat) ranged from 16+/-4% (C58/J) to 39+/-2% (NON/LtJ). In general, heavier strains had a higher %Fat (r=0.57) but several light strains were also quite fat (e.g., SPRET/EiJ, body weight=15.7+/-0.6 g, %Fat=26+/-1%). Males were significantly heavier than females in 26 strains and significantly fatter than females in 9 strains; only the KK/H1J strain had fatter females than males. Some of the fattest strains are infrequently used in obesity experiments, for example the JF1/Ms and CBA/J strains. These data illustrate the diversity of body weight and composition in inbred mice. They will serve as a reference standard and assist in the selection of strains for future work.
我们测量了来自40个近交系的约10只雄性和约10只雌性小鼠的体重和身体组成。在约16周龄、此前8周单独饲养并喂食高碳水化合物、低脂饮食（AIN-76A）的小鼠中评估身体组成。使用PIXIMus II双能X线吸收仪评估胴体瘦肉和脂肪重量，并通过脂肪提取测定法进行确认。体重范围几乎是连续的，从品系均值±标准误为11.4±0.2克（MSM/MsJ）到39.3±1.8克（NON/LtJ）。脂肪占体重的百分比（%脂肪）范围从16±4%（C58/J）到39±2%（NON/LtJ）。一般来说，较重的品系%脂肪较高（r = 0.57），但一些较轻的品系脂肪含量也相当高（例如，SPRET/EiJ，体重 = 15.7±0.6克，%脂肪 = 26±1%）。在26个品系中雄性明显比雌性重，在9个品系中雄性比雌性胖得多；只有KK/H1J品系雌性比雄性胖。一些脂肪含量最高的品系在肥胖实验中很少使用，例如JF1/Ms和CBA/J品系。这些数据说明了近交系小鼠体重和身体组成的多样性。它们将作为参考标准，有助于为未来的研究选择品系。
