Wu Q, Suzuki M
Environmental Health Sciences Division, National Institute for Environmental Studies, Onogawa, Tsukuba, Japan.
Obes Rev. 2006 May;7(2):201-8. doi: 10.1111/j.1467-789X.2006.00232.x.
The prevalence of obesity in adults has been rising continually, as has the prevalence of childhood obesity, and a large number of epidemiological studies have demonstrated a direct relationship between parental obesity and childhood obesity. In this paper, we review the effect of diet, the intrauterine environment, and the genetic inheritance on obesity. We described a study in detail that used experimental animals as a model to investigate the effect of a parental high-fat diet on body-fat accumulation in their offspring. Fertilized eggs were transplanted in that study, and body-fat accumulation in the offspring of the parents fed a high-fat diet was found to be greater than in the offspring of the parents fed a low-fat diet, even when the experimental conditions were the same in the intrauterine and subsequent environment. The results suggested that a parental high-fat diet before intrauterine developmental stage may increase body-fat accumulation in the offspring. We discuss the possibility that parental diet may influence the lifelong health of offspring and epigenetic inheritance may be occurred.
成人肥胖的患病率一直在持续上升，儿童肥胖的患病率亦是如此，并且大量的流行病学研究已证实父母肥胖与儿童肥胖之间存在直接关联。在本文中，我们综述了饮食、子宫内环境和基因遗传对肥胖的影响。我们详细描述了一项以实验动物为模型的研究，该研究旨在探究双亲高脂饮食对其后代体脂积累的影响。在该项研究中，受精卵被进行了移植，结果发现，即便子宫内及后续环境中的实验条件相同，高脂饮食双亲的后代比低脂饮食双亲的后代体脂积累更多。结果表明，在子宫内发育阶段之前双亲的高脂饮食可能会增加后代的体脂积累。我们探讨了双亲饮食可能影响后代终身健康以及可能发生表观遗传的可能性。
