在天花疫苗接种者的血液中检测到痘苗病毒DNA，但未检测到有传染性的病毒。
Detection of vaccinia virus DNA, but not infectious virus, in the blood of smallpox vaccine recipients.
作者信息
Cohen Jeffrey I, Hohman Patricia, Preuss Jeanne C, Li Li, Fischer Steven H, Fedorko Daniel P
机构信息
Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
出版信息
Vaccine. 2007 Jun 6;25(23):4571-4. doi: 10.1016/j.vaccine.2007.03.044. Epub 2007 Apr 18.
The authors of a recent study [Savona MR, Dela Cruz WP, Jones MS, Thornton JA, Xia D, Hadfield TL, et al. Detection of vaccinia DNA in the blood following smallpox vaccination. JAMA 2006; 295:1898-1900] suggested that the duration of deferral for blood donations by smallpox vaccinees should be extended, based on detection of vaccinia virus DNA in five blood samples by polymerase chain reaction (PCR) and the potential for viremia. We found that 4 of 202 blood specimens (from 3 of 27 smallpox vaccinees) were positive for vaccinia virus DNA by PCR; none were positive for virus by culture. Throat swabs were negative by PCR and culture. Thus, while some blood specimens contained vaccinia virus DNA, infectious virus was not detected. Current guidelines for deferral of blood donation in vaccinees seem appropriate.
近期一项研究[萨沃纳MR，德拉·克鲁兹WP，琼斯MS，桑顿JA，夏D，哈德菲尔德TL等。天花疫苗接种后血液中痘苗病毒DNA的检测。《美国医学会杂志》2006年；295：1898 - 1900]的作者们提出，鉴于通过聚合酶链反应（PCR）在五份血液样本中检测到痘苗病毒DNA以及存在病毒血症的可能性，天花疫苗接种者推迟献血的时间应延长。我们发现，202份血液标本中有4份（来自27名天花疫苗接种者中的3名）通过PCR检测痘苗病毒DNA呈阳性；通过培养没有一份标本病毒呈阳性。咽喉拭子经PCR和培养均为阴性。因此，虽然一些血液标本含有痘苗病毒DNA，但未检测到有传染性的病毒。目前针对疫苗接种者推迟献血的指导方针似乎是恰当的。
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