Faraone Stephen V, Biederman Joseph, Zimmerman Brenda
Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
J Atten Disord. 2007 Sep;11(2):157-66. doi: 10.1177/1087054706295663. Epub 2007 May 9.
Treatment adherence is an important aspect of ADHD symptom management, but there are many factors that may influence adherence.
This analysis assessed adherence to OROS methylphenidate during a 1-year, open-label study in children. Adherence was defined as the number of days medication was taken divided by the number of days in the study and determined to be high if > or =75%. Possible clinical and demographic factors associated with adherence, including use of planned medication breaks, were assessed.
Mean adherence was 86.4%. It was 91.6% for the subgroup of patients who reported not taking planned medication breaks (n = 252) and 77.7% for the subgroup taking planned medication breaks (n = 155). Overall, 75% of patients showed high adherence. Older age, low starting dose, minority ethnic status, and fewer ADHD symptoms were associated with low adherence.
Various factors were found to be associated with low adherence, and the results of this analysis provide guidance to physicians seeking to identify those patients with ADHD most likely not be adherent to stimulant therapy
治疗依从性是多动症症状管理的一个重要方面，但有许多因素可能会影响依从性。
该分析在一项针对儿童的为期1年的开放标签研究中评估了对奥氮平控释片的依从性。依从性定义为服药天数除以研究天数，若≥75%则判定为依从性高。评估了与依从性相关的可能的临床和人口统计学因素，包括使用计划性药物假期。
平均依从性为86.4%。报告未使用计划性药物假期的患者亚组（n = 252）的依从性为91.6%，使用计划性药物假期的患者亚组（n = 155）的依从性为77.7%。总体而言，75%的患者表现出高依从性。年龄较大、起始剂量低、少数族裔身份以及多动症症状较少与低依从性相关。
发现多种因素与低依从性相关，该分析结果为试图识别最有可能不坚持兴奋剂治疗的多动症患者的医生提供了指导。
