Seidler Randolph W, Lenter Martin C, Guth Brian D, Doods Henri
Department of Cardiovascular Disease, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, Ridgefield, CT 06877, USA.
J Cardiovasc Pharmacol Ther. 2007 Mar;12(1):61-8. doi: 10.1177/1074248406298625.
Monocyte chemoattractant protein-1 (MCP-1) is a stimulator of collateral artery growth and has been shown to increase collateral artery conductance in rabbits and pigs. The minimal infusion duration and the minimally effective dose of MCP-1 are currently unknown, as is the sustainability of the therapeutic effect over a longer observation period than tested before. MCP-1 was infused intra-arterially in pigs after unilateral femoral artery occlusion in different doses and infusion durations between 2 hours and 2 weeks. Two weeks after ligation, arterial conductance under maximal vasodilatation was measured. The long-term efficacy was investigated in 2 additional groups of animals after 6 weeks. Infusion with 2 microg/min of MCP-1 for 6 hours was sufficient to double arterial conductance, and arterial conductance after 6 weeks was still significantly increased.
单核细胞趋化蛋白-1（MCP-1）是侧支动脉生长的刺激因子，已证实在兔和猪中可增加侧支动脉传导。目前尚不清楚MCP-1的最小输注持续时间和最小有效剂量，以及在比之前测试更长的观察期内治疗效果的可持续性。在猪单侧股动脉闭塞后，以不同剂量和2小时至2周的输注持续时间动脉内输注MCP-1。结扎两周后，测量最大血管舒张下的动脉传导。在另外两组动物中于6周后研究长期疗效。以2微克/分钟的剂量输注MCP-1 6小时足以使动脉传导增加一倍，并且6周后的动脉传导仍显著增加。
