Vera Julio, Sun Cheng, Oertel Yvonne, Wolkenhauer Olaf
Systems Biology and Bioinformatics Group, Department of Computer Science. University of Rostock, 18051 Rostock, Germany.
Bioinformatics. 2007 Oct 1;23(19):2638-40. doi: 10.1093/bioinformatics/btm245. Epub 2007 May 11.
PLMaddon is a General Public License (GPL) software module designed to expand the current version of the SBToolbox (a Matlab toolbox for systems biology; www.sbtoolbox.org) with a set of functions for the analysis of power-law models, a specific class of kinetic models, set in ordinary differential equations (ODE) and in which the kinetic orders can have positive/negative non-integer values. The module includes functions to generate power-law Taylor expansions of other ODE models (e.g. Michaelis-Menten type models), as well as algorithms to estimate steady-states. The robustness and sensitivity of the models can also be analysed and visualized by computing the power-law's logarithmic gains and sensitivities.
PLMaddon是一个通用公共许可证(GPL)软件模块,旨在通过一组用于分析幂律模型的函数来扩展SBToolbox(一个用于系统生物学的Matlab工具箱;www.sbtoolbox.org)的当前版本。幂律模型是一类特定的动力学模型,用常微分方程(ODE)表示,其中动力学阶数可以有正/负非整数值。该模块包括用于生成其他ODE模型(如米氏类型模型)的幂律泰勒展开式的函数,以及估计稳态的算法。通过计算幂律的对数增益和灵敏度,还可以分析和可视化模型的稳健性和灵敏度。