Pritchett James W
Clin Orthop Relat Res. 2007 Mar;456:233-7. doi: 10.1097/BLO.0b013e31802cfa9e.
There have been numerous efforts to alter the lipid content of cardiovascular tissues. Although equally important, only limited information is available about musculoskeletal tissues. I characterized joint and bone marrow lipids in patients having joint replacement surgery and explored the effects of fish oils and statins on lipid composition in bone marrow and joint fluid. Joint drainage catheters were used to collect marrow lipids from 84 patients having 128 hip and knee replacements for osteoarthritis, osteonecrosis, and femoral neck fractures (osteoporosis). Statins reduced the amount of lipid by 22% in patients with osteoporosis, 26% in patients with osteoarthritis, and 41% in patients with osteonecrosis compared with pretreatment lipid levels in the same patients. Taking fish oils reduced the amount of lipid in bone marrow by 20%. Lipid profiles of disturbed marrow and joint fluid from patients who took statins or dietary fish oil showed an increase in the proportion of unsaturated fatty acids and longer-chain fatty acids relative to pretreatment profiles. The ability to change the amount and character of bone and joint lipids may have major importance for strengthening bone, reducing the severity or preventing osteonecrosis, and enhancing joint lubrication.
人们已经做出了许多努力来改变心血管组织的脂质含量。虽然同样重要，但关于肌肉骨骼组织的信息却非常有限。我对接受关节置换手术的患者的关节和骨髓脂质进行了表征，并探讨了鱼油和他汀类药物对骨髓和关节液脂质组成的影响。使用关节引流导管从84例因骨关节炎、骨坏死和股骨颈骨折（骨质疏松症）而进行128例髋关节和膝关节置换的患者中收集骨髓脂质。与同一患者的治疗前脂质水平相比，他汀类药物使骨质疏松症患者的脂质含量降低了22%，骨关节炎患者降低了26%，骨坏死患者降低了41%。服用鱼油使骨髓中的脂质含量降低了20%。服用他汀类药物或膳食鱼油的患者，其骨髓和关节液中紊乱的脂质谱显示，相对于治疗前的谱，不饱和脂肪酸和长链脂肪酸的比例有所增加。改变骨骼和关节脂质的数量和特性的能力可能对增强骨骼、减轻严重程度或预防骨坏死以及增强关节润滑具有重要意义。
