Lemche Erwin, Surguladze Simon A, Giampietro Vincent P, Anilkumar Ananthapadmanabha, Brammer Michael J, Sierra Mauricio, Chitnis Xavier, Williams Steven C R, Gasston David, Joraschky Peter, David Anthony S, Phillips Mary L
Section of Neuroscience and Emotion, Brain Image Analysis Unit, Neuroimaging Research Group, Centre for Neuroimaging Sciences, Institute of Psychiatry, London, UK.
Neuroreport. 2007 Mar 26;18(5):473-7. doi: 10.1097/WNR.0b013e328057deb3.
Depersonalization disorder, characterized by emotional detachment, has been associated with increased prefrontal cortical and decreased autonomic activity to emotional stimuli. Event-related fMRI with simultaneous measurements of skin conductance levels occurred in nine depersonalization disorder patients and 12 normal controls to neutral, mild and intense happy and sad facial expressions. Patients, but not controls, showed decreases in subcortical limbic activity to increasingly intense happy and sad facial expressions, respectively. For both happy and sad expressions, negative correlations between skin conductance measures in bilateral dorsal prefrontal cortices occurred only in depersonalization disorder patients. Abnormal decreases in limbic activity to increasingly intense emotional expressions, and increases in dorsal prefrontal cortical activity to emotionally arousing stimuli may underlie the emotional detachment of depersonalization disorder.
人格解体障碍以情感超脱为特征，与前额叶皮质活动增加以及对情感刺激的自主神经活动减少有关。对9名人格解体障碍患者和12名正常对照者进行了事件相关功能磁共振成像（fMRI），同时测量他们对中性、轻度和强烈的快乐及悲伤面部表情的皮肤电导水平。患者而非对照者，分别对越来越强烈的快乐和悲伤面部表情表现出皮质下边缘系统活动减少。对于快乐和悲伤表情，双侧背侧前额叶皮质的皮肤电导测量值之间的负相关仅出现在人格解体障碍患者中。对越来越强烈的情感表情的边缘系统活动异常减少，以及对情感唤起刺激的背侧前额叶皮质活动增加，可能是人格解体障碍情感超脱的基础。
