Konuk N, Tekin I O, Ozturk U, Atik L, Atasoy N, Bektas S, Erdogan A
Department of Psychiatry, Faculty of Medicine, Zonguldak Karaelmas University, 67600 Zonguldak, Turkey.
Mediators Inflamm. 2007;2007:65704. doi: 10.1155/2007/65704. Epub 2007 Feb 27.
Recent research implicated place of an immune mechanism in the pathophysiology of obsessive-compulsive disorder (OCD). Despite increasing evidence involvement of cytokine release in OCD, results of the studies are inconsistent. The aim of this study was to evaluate the plasma levels of the cytokines; tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in OCD patients.
Plasma concentrations of TNF-alpha and IL-6 were measured in 31 drug-free outpatients with OCD, and 31-year age and sex-matched healthy controls. TNF-alpha and IL-6 concentrations in blood were determined by enzyme-linked immunosorbent assay (ELISA).
Both TNF-alpha and IL-6 levels showed statistically significant increases in OCD patients compared to controls (P < .000, P < .001, resp.). In addition, the age of onset was negatively correlated with TNF-alpha level (r = -.402, P = .025) and duration of illness was weakly correlated with IL-6 levels (r: .357; P: .048) in patients group.
OCD patients showed increases in TNF-alpha and IL-6 levels compared to the healthy controls. This study provides evidence for alterations in the proinflammatory cytokines which suggest the involvement of the immune system in the pathophysiology of OCD.
近期研究表明免疫机制在强迫症（OCD）的病理生理学中发挥作用。尽管越来越多的证据表明细胞因子释放与强迫症有关，但研究结果并不一致。本研究的目的是评估强迫症患者血浆中细胞因子肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）的水平。
测定了31名未服用药物的强迫症门诊患者以及31名年龄和性别匹配的健康对照者血浆中TNF-α和IL-6的浓度。采用酶联免疫吸附测定法（ELISA）测定血液中TNF-α和IL-6的浓度。
与对照组相比，强迫症患者的TNF-α和IL-6水平均有统计学意义的升高（分别为P <.000，P <.001）。此外，在患者组中，发病年龄与TNF-α水平呈负相关（r = -.402，P =.025），病程与IL-6水平呈弱相关（r:.357；P:.048）。
与健康对照相比，强迫症患者的TNF-α和IL-6水平升高。本研究为促炎细胞因子的改变提供了证据，提示免疫系统参与了强迫症的病理生理学过程。
