Carpenter Linda L, Heninger George R, McDougle Christopher J, Tyrka Audrey R, Epperson C Neill, Price Lawrence H
Mood Disorders Research Program, Butler Hospital, and Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, 345 Blackstone Boulevard, Providence, RI 02906, USA.
Psychiatry Res. 2002 Nov 15;112(3):257-62. doi: 10.1016/s0165-1781(02)00233-0.
Recent studies have suggested that neuroimmune abnormalities may play an important role in the pathogenesis of obsessive-compulsive disorder (OCD) and related disorders. This study was undertaken to determine whether cerebrospinal fluid (CSF) concentrations of the proinflammatory cytokine interleukin (IL)-6 differ between OCD and trichotillomania patients and healthy control subjects. Lumbar puncture with a standardized procedure was performed on 26 patients with OCD and 9 with trichotillomania. All patients were drug-free and met DSM-IV criteria. Twenty-six age- and sex-matched healthy volunteers underwent the same procedure. CSF was assayed for IL-6 using a quantitative 'sandwich' enzyme immunoassay technique. Mean+/-S.D. CSF IL-6 levels did not differ between OCD patients (n=26) (2.4+/-1.1 pg/ml) and controls (n=26) (2.4+/-1.9 pg/ml) or between trichotillomania patients (n=9) (2.3+/-0.8 pg/ml) and their matched controls (n=14) (1.9+/-0.5 pg/ml). These findings fail to support speculation that ongoing immune activation may be causally involved in the pathogenesis of OCD or trichotillomania.
近期研究表明，神经免疫异常可能在强迫症（OCD）及相关疾病的发病机制中起重要作用。本研究旨在确定OCD患者、拔毛癖患者与健康对照者之间脑脊液（CSF）中促炎细胞因子白细胞介素（IL）-6的浓度是否存在差异。对26例OCD患者和9例拔毛癖患者进行了标准化程序的腰椎穿刺。所有患者均未用药且符合DSM-IV标准。26名年龄和性别匹配的健康志愿者接受了相同的程序。使用定量“夹心”酶免疫测定技术检测CSF中的IL-6。OCD患者（n = 26）（2.4±1.1 pg/ml）与对照组（n = 26）（2.4±1.9 pg/ml）之间，或拔毛癖患者（n = 9）（2.3±0.8 pg/ml）与其匹配对照组（n = 14）（1.9±0.5 pg/ml）之间，CSF中IL-6的平均±标准差水平无差异。这些发现不支持持续免疫激活可能与OCD或拔毛癖发病机制存在因果关系的推测。
