Chen Chih-Hao, Liu Hung-Chang, Tung Kwang-Yi, Lee Jie-Jen, Liu Chien-Liang, Liu Tsang-Pai
Department of Surgery, Mackay Memorial Hospital, Taipei City, Taiwan.
ANZ J Surg. 2007 May;77(5):339-43. doi: 10.1111/j.1445-2197.2007.04055.x.
Castleman disease is a rare lymphoproliferative disease of low malignant potential occurring in two forms, unicentric and multicentric. Surgery, chemotherapy, immunotherapy and radiation therapy have all been used to manage the disease. In this study, we evaluate whether the site of the lesions, that is, superficial or deep, influences the surgical outcome.
We retrospectively reviewed the records of 20 patients operated on for Castleman disease from 1994 to 2003, of whom 11 patients had superficial disease and 9 had deep lesions. The end-points of this study were survival and recurrence.
Of the 20 patients, 19 had unicentric (cervical in 8, mediastinal in 5, retroperitoneal in 2, axillary in 2, hepatic in 1, and mesenteric in 1) and 1 had multicentric Castleman disease. Among 19 patients who had complete resection (18 with unicentric and 1 with multicentric disease), there has been no evidence of recurrence.
Whether Castleman disease is superficial or deep has no effect on surgical outcome as long as resection is complete.
卡斯特曼病是一种罕见的具有低恶性潜能的淋巴增生性疾病，有单中心型和多中心型两种形式。手术、化疗、免疫治疗和放射治疗都已被用于治疗该疾病。在本研究中，我们评估病变部位，即浅表或深部，是否会影响手术结果。
我们回顾性分析了1994年至2003年期间接受卡斯特曼病手术治疗的20例患者的记录，其中11例为浅表疾病患者，9例为深部病变患者。本研究的终点指标为生存率和复发率。
20例患者中，19例为单中心型（8例位于颈部，5例位于纵隔，2例位于腹膜后，2例位于腋窝，1例位于肝脏，1例位于肠系膜），1例为多中心型卡斯特曼病。在19例接受完整切除的患者中（18例单中心型和1例多中心型疾病），没有复发的证据。
只要切除完整，卡斯特曼病是浅表还是深部对手术结果没有影响。
